Efficacy of the Ketogenic Diet as a Treatment Option for Epilepsy: Meta-analysis
| Autor: | Stephen C. Alder, Joseph L. Lyon, C. Beth Henderson, Francis Filloux, Deirdre A. Caplin |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Pediatrics Patient Dropouts Time Factors Adolescent medicine.medical_treatment Diet Carbohydrate-Restricted 03 medical and health sciences Epilepsy 0302 clinical medicine 030225 pediatrics Internal medicine Diet Protein-Restricted Odds Ratio medicine Humans Child business.industry Infant Ketosis Odds ratio medicine.disease Confidence interval Diet Discontinuation Treatment Outcome Endocrinology Child Preschool Meta-analysis Pediatrics Perinatology and Child Health Female Observational study Neurology (clinical) business 030217 neurology & neurosurgery Follow-Up Studies Ketogenic diet |
| Zdroj: | Journal of Child Neurology. 21:193-198 |
| ISSN: | 1708-8283 0883-0738 |
| DOI: | 10.2310/7010.2006.00044 |
| Popis: | The evidence base for the efficacy of the ketogenic diet was assessed among pediatric epileptic patients by application of a rigorous statistical meta-analysis. Nineteen studies from 392 abstracts met the inclusion criteria. The sample size was 1084 patients (mean age at initiation 5.78 ± 3.43 years). The pooled odds ratio, using a random effects model, of treatment success (> 50% seizure reduction) among patients staying on the diet relative to those discontinuing the diet was 2.25 (95% confidence interval = 1.69—2.98). The reasons for diet discontinuation included < 50% seizure reduction (47.0%), diet restrictiveness (16.4%), and incurrent illness or diet side effects (13.2%). The results indicate that children with generalized seizures and patients who respond with > 50% seizure reduction within 3 months tend to remain on the diet longer. Although no class I or II studies have been published regarding the efficacy of the ketogenic diet, this meta-analysis shows that current observational studies reporting on the therapeutic effect of the ketogenic diet contain valuable statistical data. Future observational studies should aim for long-term follow-up, patient dropout analysis, and improved seizure type characterization. ( J Child Neurol 2006;21:193—198; DOI 10.2310/7010.2006.00044). |
| Databáze: | OpenAIRE |
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