The esophageal dose–volume parameters for predicting Grade I–II acute esophagitis correlated with weight loss and serum albumin decrease in lung cancer radiotherapy
| Autor: | Emine Elif Ozkan, Zumrut Arda Kaymak Cerkesli, Alper Ozseven |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Organs at Risk medicine.medical_specialty Lung Neoplasms Side effect medicine.medical_treatment Serum albumin Gastroenterology Weight loss Carcinoma Non-Small-Cell Lung Internal medicine Weight Loss medicine Esophagitis Humans Radiology Nuclear Medicine and imaging Esophagus Radiation Injuries Lung cancer Serum Albumin Retrospective Studies Acute Esophagitis biology business.industry Weight change Radiotherapy Dosage General Medicine medicine.disease Radiation therapy medicine.anatomical_structure Oncology Acute Disease biology.protein Female Radiotherapy Conformal medicine.symptom business |
| Zdroj: | Journal of Cancer Research and Therapeutics. 17:94 |
| ISSN: | 0973-1482 |
| Popis: | Introduction: Acute esophagitis (AE) is a commonly encountered side effect of curative thoracic radiotherapy (CTRT) for lung cancer patients. Nevertheless, its identification for widely used scoring systems depends on patients' statements. It is aimed to evaluate the correlation between the esophagus doses during CTRT and Grade 1–2 AE, weight change, and change in serum albumin (Alb) levels. Subjects and Methods: The data collected from 124 lung cancer patients treated with ≥60 Gy CTRT were evaluated retrospectively. Weight and serum Alb level difference of each patient, throughout CTRT, were calculated. The percentage of the esophagus volume receiving ≥5 Gy (V5), V10, V35, V50, and V60; the absolute esophagus volume receiving ≥60 Gy (V60(cc)); the length of esophagus receiving ≥60 Gy (L60); the average esophagus dose (Dmean); and the maximum esophagus dose (Dmax) were the dose parameters calculated. The correlations were performed by Spearman's rank correlation coefficient. Results: Grade 1 and Grade 2 AE were reported in 62 and 25 patients, respectively. All of the dose parameters were correlated with Grade 1–2 AE (P Conclusions: The correlation of the dose parameters that might be effective on Grade 1–2 AE with the weight loss and Alb loss was investigated, and the cutoff values corresponding to the best sensitivity and specificity were identified. |
| Databáze: | OpenAIRE |
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