Identification of 2C-B in hair by UHPLC-HRMS/MS. A real forensic case
| Autor: | Carmen García-Ruiz, Gemma Montalvo, José Manuel Matey, Adrián López-Fernández, Félix Zapata, María A. Martínez |
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| Přispěvatelé: | Universidad de Alcalá. Departamento de Química Analítica, Química Física e Ingeniería Química |
| Rok vydání: | 2021 |
| Předmět: |
Nexus
Drugs of abuse “pink cocaine” Computer science Health Toxicology and Mutagenesis Uhplc hrms Psychoactive substance UHPLC-HRMS/MS Case Report TP1-1185 Toxicology Orbitrap NPS 01 natural sciences law.invention pink cocaine 03 medical and health sciences 0302 clinical medicine law 030216 legal & forensic medicine Volume concentration Chemical Health and Safety Chromatography Chemical technology 010401 analytical chemistry 2C-B hair Química 0104 chemical sciences Identification (information) Chemistry hallucinogens |
| Zdroj: | e_Buah Biblioteca Digital Universidad de Alcalá Universidad de Alcalá (UAH) Toxics, Vol 9, Iss 170, p 170 (2021) instname Toxics |
| Popis: | The analysis of drugs of abuse in hair and other biological matrices of forensic inter- 19 est requires great selectivity and sensitivity. This has been traditionally achieved through target 20 analysis, using one or more analytical methods that include different preanalytical stages, and 21 more complex procedures followed by toxicological laboratories. There is no exception with 2C- 22 series drugs, such as 2C-B, a new psychoactive substance (NPS), which use has emerged and sig- 23 nificantly increased, year by year, in the last decades. Continuously new analytical methods are 24 required to selectively detect and identify these new marketed substances at very low concentra- 25 tions. In this case report, one former case of a polydrug consumer (charged of a crime against pub- 26 lic health in Spain) was reanalyzed in hair matrix. In this reanalysis, 2C-B has been positively de- 27 tected and identified using liquid chromatography coupled to high-resolution mass spectrometry 28 (UHPLC-HRMS/MS). The most selective analytical UHPLC-HRMS/MS method alongside a uni- 29 versal and simpler pretreatment methodology has opened up more possibilities for detection of 30 substances of different chemical structure and optimization of different HRMS/MS detection ap- 31 proaches allowing the identification of 2-CB in the hair of a real forensic case. Instituto Universitario de Investigación en Ciencias Policiales (IUICP) |
| Databáze: | OpenAIRE |
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