Quantitative determination of p-chlorophenoxyisobutyric acid in blood plasma by gas—liquid chromatography
| Autor: | Tuong Chi Cuong, Anne Tuong |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Chromatography
Gas Chromatography P-Chlorophenoxyisobutyric Acid Diazomethane Organic Chemistry Pyridoxine General Medicine Plasma levels Hydrogen-Ion Concentration Methylation Biochemistry Quantitative determination Analytical Chemistry chemistry.chemical_compound Residue (chemistry) chemistry Alcohols Blood plasma Clofibrate Glass Gas chromatography Benzene |
| Zdroj: | Journal of Chromatography A. 106:97-102 |
| ISSN: | 0021-9673 |
| Popis: | A gas—liquid chromatographic method for the determination of p -chlorophenoxyisobutyric (CPIB) acid in blood plasma is described. The substance is extracted from acidified plasma into benzene, the extract is evaporated to dryness and the residue is methylated with an alcohol-free solution of diazomethane and submitted to chromatography on a glass column packed with 3% OV-17. Data on the recovery, reproducibility and sensitivity of the method are given. CPIB acid plasma levels in rats after acute and prolonged treatments with the aluminium salt of CPIB acid (Atherolip) are also presented. |
| Databáze: | OpenAIRE |
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