Gastric pH profiles of beagle dogs and their use as an alternative to human testing
| Autor: | Shohei Higuchi, Masayuki Akimoto, Naokazu Nagahata, Kiyomi Fukushima, Toshio Suwa, Atsushi Furuya |
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| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Pharmaceutical Science Ranitidine Placebo Beagle Gastroenterology Dogs Pharmacokinetics Internal medicine Animals Humans Medicine business.industry Stomach digestive oral and skin physiology Capsule Gastric Acidity Determination General Medicine Hydrogen-Ion Concentration Pentagastrin medicine.anatomical_structure Endocrinology Distilled water business Biotechnology medicine.drug |
| Zdroj: | European Journal of Pharmaceutics and Biopharmaceutics. 49:99-102 |
| ISSN: | 0939-6411 |
| DOI: | 10.1016/s0939-6411(99)00070-3 |
| Popis: | Gastric pH levels were measured in samples of gastric aspirates from eight fasted beagle dogs. The gastric pH in fasting dogs fluctuated from 2.7 to 8.3, with a mean of 6.8±0.2 (SE). Each dog received the following four treatments in randomly-assigned order: (A) distilled water; (B) a placebo capsule; (C) pentagastrin, and (D) ranitidine. The gastric pH remained relatively constant after distilled water administration. In contrast, the treatments with pentagastrin and placebo capsule each lowered gastric pH. Pretreatment with pentagastrin was more successful in lowering gastric pH than that with placebo capsule. On the other hand, the pH rose above 7.0 in all dogs by the first hour after treatment with ranitidine. This animal model may be helpful in evaluating the biopharmaceutics of drugs exhibiting pH-dependent dissolution or decomposition. |
| Databáze: | OpenAIRE |
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