Genetic and environmental variation in educational attainment: an individual-based analysis of 28 twin cohorts

Autor:	Catharina E. M. van Beijsterveldt, Ruth J. F. Loos, Margaret Gatz, Soo Ji Lee, Anna K. Dahl Aslan, William S. Kremen, Dorret I. Boomsma, Adam Domonkos Tarnoki, Esther Rebato, Jessica Tyler, David Laszlo Tarnoki, Zengchang Pang, Norio Sakai, Jaakko Kaprio, Reijo Sund, Fujio Inui, Michael J. Lyons, Grant W. Montgomery, Andreas Busjahn, Karri Silventoinen, Hang A Park, Juan R. Ordoñana, Finn Rasmussen, Lucía Colodro-Conde, Patrik K. E. Magnusson, Brooke M. Huibregtse, Sisira Siribaddana, Shandell Pahlen, John L. Hopper, Fruhling Rijsdijk, Keith E. Whitfield, Thomas M. Mack, Nicholas G. Martin, Tracy L. Nelson, Meike Bartels, Jooyeon Lee, Virgilia Toccaceli, Joohon Sung, Carol E. Franz, Thorkild I. A. Sørensen, Catherine Derom, Matthew Hotopf, Dedra Buchwald, Robert F. Krueger, David A. Butler, Thomas Sevenius Nilsen, Sarah E. Medland, Judy L. Silberg, Emanuela Medda, Jennifer R. Harris, Paulo H. Ferreira, Matt McGue, Antti Latvala, Per Tynelius, Nancy L. Pedersen, Aline Jelenkovic, Amie E. Hwang, Glen E. Duncan, Lucas Calais-Ferreira, Juan F. Sánchez-Romera, Athula Sumathipala, Yoshie Yokoyama, Qihua Tan, Ingunn Brandt, Rie Tomizawa, Chika Honda, Mikio Watanabe, Robert F. Vlietinck, Dongfeng Zhang, Gonneke Willemsen, Hermine H. Maes, Robin P. Corley, Vinícius Cunha Oliveira, Christian Kandler, Lorenza Nisticò
Přispěvatelé:	Helsinki Inequality Initiative (INEQ), Population Research Unit (PRU), Center for Population, Health and Society, Sociology, University of Helsinki, Clinicum, Department of Public Health, Department of Social Research (2010-2017), Institute of Criminology and Legal Policy, Institute for Molecular Medicine Finland, HUS Helsinki and Uusimaa Hospital District, Biological Psychology, APH - Health Behaviors & Chronic Diseases, APH - Mental Health, APH - Personalized Medicine, APH - Methodology
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Male 0301 basic medicine Netherlands Twin Register (NTR) 6162 Cognitive science inequality lcsh:Medicine heritability PHENOTYPE Cohort Studies human experiment cognitive-ability 0302 clinical medicine traits environmental factor Twins Dizygotic Medicine and Health Sciences Psychology Pooled data Gene–environment interaction lcsh:Science media_common education Academic Success Multidisciplinary Asia Eastern HERITABILITY adult article Public Health Global Health Social Medicine and Epidemiology 3. Good health Europe Geography female Educational Status Female LB TRAITS Cohort study metaanalysis Adult Asia Inequality phenotype media_common.quotation_subject mental capacity Article 03 medical and health sciences Individual based Quantitative Trait Heritable male Genetics Humans human Genetik METAANALYSIS lcsh:R Australia Twins Monozygotic Heritability Environmental variation COGNITIVE-ABILITY Educational attainment Folkhälsovetenskap global hälsa socialmedicin och epidemiologi 030104 developmental biology genetic variation North America lcsh:Q Gene-Environment Interaction INEQUALITY 030217 neurology & neurosurgery Demography meta analysis
Zdroj:	Silventoinen, K, Jelenkovic, A, Sund, R, Latvala, A, Honda, C, Inui, F, Tomizawa, R, Watanabe, M, Sakai, N, Rebato, E, Busjahn, A, Tyler, J, Hopper, J L, Ordoñana, J R, Sánchez-Romera, J F, Colodro-Conde, L, Calais-Ferreira, L, Oliveira, V C, Ferreira, P H, Medda, E, Nisticò, L, Toccaceli, V, Derom, C A, Vlietinck, R F, Loos, R J F, Siribaddana, S H, Hotopf, M, Sumathipala, A, Rijsdijk, F, Duncan, G E, Buchwald, D, Tynelius, P, Rasmussen, F, Tan, Q, Zhang, D, Pang, Z, Magnusson, P K E, Pedersen, N L, Aslan, A K D, Hwang, A E, Mack, T M, Krueger, R F, McGue, M, Pahlen, S, Brandt, I, Nilsen, T S, Harris, J R, Martin, N G, Medland, S E, Montgomery, G W, Willemsen, G, Bartels, M, van Beijsterveldt, C E M, Franz, C E, Kremen, W S, Lyons, M J, Silberg, J L, Maes, H H, Kandler, C, Nelson, T L, Whitfield, K E, Corley, R P, Huibregtse, B M, Gatz, M, Butler, D A, Tarnoki, A D, Tarnoki, D L, Park, H A, Lee, J, Lee, S J, Sung, J, Yokoyama, Y, Sørensen, T I A, Boomsma, D I & Kaprio, J 2020, ' Genetic and environmental variation in educational attainment : an individual-based analysis of 28 twin cohorts ', Scientific Reports, vol. 10, no. 1, 12681 . https://doi.org/10.1038/s41598-020-69526-6 Addi. Archivo Digital para la Docencia y la Investigación instname Silventoinen, K, Jelenkovic, A, Sund, R, Latvala, A, Honda, C, Inui, F, Tomizawa, R, Watanabe, M, Sakai, N, Rebato, E, Busjahn, A, Tyler, J, Hopper, J L, Ordoñana, J R, Sánchez-Romera, J F, Colodro-Conde, L, Calais-Ferreira, L, Oliveira, V C, Ferreira, P H, Medda, E, Nisticò, L, Toccaceli, V, Derom, C A, Vlietinck, R F, Loos, R J F, Siribaddana, S H, Hotopf, M, Sumathipala, A, Rijsdijk, F, Duncan, G E, Buchwald, D, Tynelius, P, Rasmussen, F, Tan, Q, Zhang, D, Pang, Z, Magnusson, P K E, Pedersen, N L, Dahl Aslan, A K, Hwang, A E, Mack, T M, Krueger, R F, McGue, M, Pahlen, S, Brandt, I, Nilsen, T S, Harris, J R, Martin, N G, Medland, S E, Montgomery, G W, Willemsen, G, Bartels, M, van Beijsterveldt, C E M, Franz, C E, Kremen, W S, Lyons, M J, Silberg, J L, Maes, H H, Kandler, C, Nelson, T L, Whitfield, K E, Corley, R P, Huibregtse, B M, Gatz, M, Butler, D A, Tarnoki, A D, Tarnoki, D L, Park, H A, Lee, J, Lee, S J, Sung, J, Yokoyama, Y, Sørensen, T I A, Boomsma, D I & Kaprio, J 2020, ' Genetic and environmental variation in educational attainment : an individual-based analysis of 28 twin cohorts ', Scientific Reports, vol. 10, no. 1, 12681, pp. 1-11 . https://doi.org/10.1038/s41598-020-69526-6, https://doi.org/10.1038/s41598-020-69526-6 SCIENTIFIC REPORTS Scientific Reports Scientific Reports, 10(1):12681, 1-11. Nature Publishing Group Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) Universidad de Cantabria (UC) Addi: Archivo Digital para la Docencia y la Investigación Universidad del País Vasco
ISSN:	2045-2322
Popis:	We investigated the heritability of educational attainment and how it differed between birth cohorts and cultural-geographic regions. A classical twin design was applied to pooled data from 28 cohorts representing 16 countries and including 193,518 twins with information on educational attainment at 25 years of age or older. Genetic factors explained the major part of individual differences in educational attainment (heritability: a(2)=0.43; 0.41-0.44), but also environmental variation shared by co-twins was substantial (c(2)=0.31; 0.30-0.33). The proportions of educational variation explained by genetic and shared environmental factors did not differ between Europe, North America and Australia, and East Asia. When restricted to twins 30 years or older to confirm finalized education, the heritability was higher in the older cohorts born in 1900-1949 (a(2)=0.44; 0.41-0.46) than in the later cohorts born in 1950-1989 (a(2)=0.38; 0.36-0.40), with a corresponding lower influence of common environmental factors (c(2)=0.31; 0.29-0.33 and c(2)=0.34; 0.32-0.36, respectively). In conclusion, both genetic and environmental factors shared by co-twins have an important influence on individual differences in educational attainment. The effect of genetic factors on educational attainment has decreased from the cohorts born before to those born after the 1950s. This study was conducted within the CODATwins project. We thank Wendy Cozen, University of Southern California, for sharing data with us. Funding for collaborators: Netherlands Twin Register acknowledges the Netherlands Organization for Scientific Research (NWO) and MagW/ZonMW grants 904-61-090, 985-10-002, 912-10-020, 904-61-193,480-04-004, 463-06-001, 451-04-034, 400-05-717, Addiction-31160008, Middelgroot-911-09-032, Spinozapremie 56-464-14192; VU University's Institute for Health and Care Research (EMGO+); the European Research Council (ERC - 230374), the Avera Institute, Sioux Falls, South Dakota (USA). Data collection and analyses in Finnish twin cohorts have been supported by ENGAGE - European Network for Genetic and Genomic Epidemiology, FP7-HEALTH-F4-2007, Grant Agreement Number 201413, National Institute of Alcohol Abuse and Alcoholism (Grants AA-12502, AA-00145, and AA-09203 to R J Rose, the Academy of Finland Center of Excellence in Complex Disease Genetics (Grant Numbers: 213506, 129680), and the Academy of Finland (Grants 100499, 205585, 118555, 141054, 265240, 263278 and 264146 to J Kaprio). Since its origin the East Flanders Prospective Survey has been partly supported by grants from the Fund of Scientific Research, Flanders and Twins, a non-profit Association for Scientific Research in Multiple Births (Belgium). Anthropometric measurements of the Hungarian twins were supported by Medexpert Ltd., Budapest, Hungary. The Murcia Twin Registry is supported by Fundacion Seneca, Regional Agency for Science and Technology, Murcia, Spain (08633/PHCS/08, 15302/PHCS/10 & 19479/PI/14) and Ministry of Science and Innovation, Spain (PSI2009-11560 & PSI2014-56680-R). K Silventoinen is supported by Osaka University's International Joint Research Promotion Program. We acknowledge The Swedish Twin Registry for access to data. The Swedish Twin Registry is managed by Karolinska Institutet and receives funding through the Swedish Research Council under the grant no 2017-00641. This research was facilitated through access to Twins Research Australia, a national resource supported by a Centre of Research Excellence Grant (ID: 1079102), from the National Health and Medical Research Council. California Twin Program was supported by The California Tobacco-Related Disease Research Program (7RT-0134H, 8RT-0107H, 6RT-0354H) and the National Institutes of Health (1R01ESO15150-01). The Carolina African American Twin Study of Aging (CAATSA) was funded by a grant from the National Institute on Aging (grant 1RO1-AG13662-01A2) to K. E. Whitfield. Colorado Twin Registry is funded by NIDA funded center grant DA011015, & Longititudinal Twin Study HD10333; Author Huibregtse is supported by 5T32DA017637 and 5T32AG052371. Washington State Twin Registry (formerly the University of Washington Twin Registry) was supported in part by grant NIH RC2 HL103416 (D. Buchwald, PI). Vietnam Era Twin Study of Aging was supported by National Institute of Health grants NIA R01 AG018384, R01 AG018386, R01 AG022381, and R01 AG022982, and, in part, with resources of the VA San Diego Center of Excellence for Stress and Mental Health. The Cooperative Studies Program of the Office of Research & Development of the United States Department of Veterans Affairs has provided financial support for the development and maintenance of the Vietnam Era Twin (VET) Registry. The content of this manuscript is solely the responsibility of the authors and does not necessarily represent the official views of the NIA/NIH, or the VA. The NAS-NRC Twin Registry acknowledges financial support from the National Institutes of Health grant number R21 AG039572. Korean Twin-Family Register was supported by the Global Research Network Program of the National Research Foundation (NRF 2011-220-E00006). Osaka University Aged Twin Registry is supported by grants from JSPS KAKENHI JP (23593419, 24792601, 26671010, 24590695, 26293128, 16K15385, 16K15978, 16K15989, 16H03261).
Databáze:	OpenAIRE
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