The effect of central nervous system agents on rat-brain γ-aminobutyric acid level
| Autor: | Richard A. Ferrari, Aaron Arnold |
|---|---|
| Rok vydání: | 1961 |
| Předmět: |
Central Nervous System
chemistry.chemical_classification Ethanol Biochemical Phenomena medicine.drug_class Central nervous system Brain General Medicine Biology Pharmacology Aminobutyric acid gamma-Aminobutyric acid Amino acid chemistry.chemical_compound medicine.anatomical_structure chemistry medicine Depressant Phenobarbital Amino Acids Pentylenetetrazol gamma-Aminobutyric Acid Central Nervous System Agents medicine.drug |
| Zdroj: | Biochimica et Biophysica Acta. 52:361-367 |
| ISSN: | 0006-3002 |
| DOI: | 10.1016/0006-3002(61)90685-0 |
| Popis: | γ-Aminobutyric acid has been implicated as a central nervous system neurohumoral depressant by a number of investigators. The hypothesis that brain excitability is inversely proportional to the γ-aminobutyric acid content was tested with compounds that were reported active by others and with a number of central nervous system stimulants and depressants. Of twelve compounds tested, e.g. , ethanol, hydroxylamine, pentylenetetrazol and phenobarbital, none produced dramatic changes in rat-brain γ-aminobutyric acid content. It was concluded that the presence of γ-aminobutyric acid in central nervous system tissue alone does not imply a physiological role a priori . |
| Databáze: | OpenAIRE |
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