Clinicopathological and molecular study of penile melanoma
| Autor: | C Corbishley, N A C S Wong, Nick Watkin, D Dickerson, Jon Oxley, L Down |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Proto-Oncogene Proteins B-raf Oncology medicine.medical_specialty Pathology Skin Neoplasms Time Factors DNA Mutational Analysis Kaplan-Meier Estimate medicine.disease_cause Pathology and Forensic Medicine Exon symbols.namesake Internal medicine medicine Humans Genetic Predisposition to Disease Codon Melanoma Penile Neoplasms neoplasms Gene Lymph node Aged Aged 80 and over Sanger sequencing Mutation business.industry Exons General Medicine Middle Aged Prognosis medicine.disease United Kingdom Survival Rate BRAF V600E Proto-Oncogene Proteins c-kit Phenotype medicine.anatomical_structure Lymphatic Metastasis symbols Clinicopathological features business |
| Zdroj: | Journal of Clinical Pathology. 65:228-231 |
| ISSN: | 1472-4146 0021-9746 |
| Popis: | Aims To examine the clinicopathological features of a series of penile melanomas and screen for mutations in the BRAF and KIT genes, which are seen in melanomas from other sites. Methods and results 12 patients with penile melanoma were identified over a 10-year period in two supra-regional networks in the UK. The 2- and 5-year survival was 61% and 20%, respectively. Half the patients had lymph node involvement at presentation; this was a poor prognostic indicator. KIT exons 11, 13, 17 and 18, and BRAF codons 600 and 601 were analysed for mutations by Sanger sequencing and pyrosequencing, respectively. None of the tumours showed either KIT mutations or the BRAF V600E mutation. Conclusion Penile melanomas are extremely rare and have a similar prognosis to melanomas elsewhere, but they often present late, leading to a poor outcome. The mutations seen in melanomas from other sites appear to be rarely present in these tumours. |
| Databáze: | OpenAIRE |
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