Primitive neuroectodermal tumors in the central nervous system following cranial irradiation
| Autor: | John A. Maguire, Katerina Drovini-Zis, Walter J. Hader |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Neoplasms Radiation-Induced Adolescent medicine.medical_treatment Craniospinal Irradiation medicine Humans Neuroectodermal Tumors Primitive Child Neuroectodermal tumor Radiotherapy Pilocytic astrocytoma Brain Neoplasms business.industry Astrocytoma Cancer medicine.disease Radiation therapy Oncology Primitive neuroectodermal tumor Female Cranial Irradiation Differential diagnosis business |
| Zdroj: | Cancer. 97:1072-1076 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/cncr.11121 |
| Popis: | BACKGROUND Radiation induced intracranial neoplasms are uncommon but well described and include gliomas, meningiomas, and sarcomas. The development of primitive neuroectodermal tumors (PNETs) following prophylactic craniospinal irradiation has been infrequently reported previously. The authors present four additional cases of PNETs that developed after previous cranial irradiation. METHODS Four patients who had previously been irradiated were determined to have PNETs of the central nervous system characterized by histopathologic and immunohistochemical features. The average patient age at diagnosis of the initial tumors and cranial irradiation was 17 years. The PNETs developed 5, 11, 11, and 18 years after completion of radiation. RESULTS Three patients had posterior fossa tumors, one pilocytic astrocytoma, one low grade astrocytoma, and one malignant ependymoma, which had been diagnosed and treated in childhood. Two of those patients developed supratentorial PNETs and the third a cerebellar hemispheric PNET. The fourth patient developed a posterior fossa PNET following irradiation for a temporal astrocytoma, which was initially diagnosed and resected at 37 years of age. Mean survival was 12 months after diagnosis. CONCLUSIONS The development of PNETs after cranial irradiation may be more common than thought previously and should be considered in the differential diagnosis of irradiation induced neoplasms. Survival after diagnosis of these radiation induced PNETs was short, and this may reflect an inability to provide standard therapy used for primary PNETs. Cancer 2003;97:1072–6. © 2003 American Cancer Society. DOI 10.1002/cncr.11121 |
| Databáze: | OpenAIRE |
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