A tautomeric ligand enables directed C‒H hydroxylation with molecular oxygen
| Autor: | Kap-Sun Yeung, William R. Ewing, Jin-Quan Yu, Zhen Li, Shaoqun Qian, Nikita Chekshin, Zhen Wang, Jennifer X. Qiao, Peter T. W. Cheng |
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| Rok vydání: | 2021 |
| Předmět: |
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Molecular Denticity Pyridines Pyridones Carboxylic Acids Hydroxylation Ligands Article Catalysis chemistry.chemical_compound Pyridine Acids Heterocyclic Multidisciplinary Molecular Structure Ligand Aryl Hydrogen Bonding Tautomer Combinatorial chemistry Carbon Oxygen chemistry Catalytic cycle Palladium Hydrogen |
| Zdroj: | Science |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | Easing oxygen into arenes Although oxygen is all around us, it is often surprisingly difficult to use it for selective chemical oxidations, necessitating more expensive, wasteful alternatives. Li et al. report that careful ligand optimization produces palladium catalysts that can efficiently activate oxygen to hydroxylate a variety of aryl and heteroaromatic rings adjacent to a carboxylic acid substituent. The ligand binds to palladium through pyridine and pyridone components, and the authors posit that tautomerization between dative and anionic coordination modes plays a role in its effectiveness. Science , abg2362, this issue p. 1452 |
| Databáze: | OpenAIRE |
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