Population-based surveys of antibodies against SARS-CoV-2 in Southern Brazil
| Autor: | Maria Letícia Rodrigues Ikeda, Fernando C. Barros, Gabriel D. Victora, Bernardo L. Horta, Mariângela F Silveira, Aluísio J D Barros, Andréia Rosane de Moura Valim, Marcelo Nascimento Burattini, Marinel Mór Dall’Agnol, Jeovany M Mesa, Marina Mantesso, Pedro C. Hallal, Odir Antônio Dellagostin, Lucia Campos Pellanda, Marilia Arndt Mesenburg, Cesar G. Victora, Claudio J. Struchiner, Ana M. B. Menezes, Fernando Pires Hartwig, Raqueli A Bittencourt, Evelise Moraes Berlezi |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine 2019-20 coronavirus outbreak Adolescent Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Pneumonia Viral Population Population based Antibodies Viral General Biochemistry Genetics and Molecular Biology Betacoronavirus Young Adult 03 medical and health sciences 0302 clinical medicine Seroepidemiologic Studies Humans Medicine Seroprevalence Child education Pandemics Viral immunology Aged Aged 80 and over education.field_of_study SARS-CoV-2 business.industry COVID-19 Infant General Medicine Middle Aged Confidence interval 030104 developmental biology Immunoglobulin M Child Preschool 030220 oncology & carcinogenesis Female Coronavirus Infections business Brazil Demography |
| Zdroj: | Nature Medicine |
| ISSN: | 1546-170X 1078-8956 |
| DOI: | 10.1038/s41591-020-0992-3 |
| Popis: | Population-based data on COVID-19 are urgently needed. We report on three rounds of probability sample household surveys in the state of Rio Grande do Sul (Brazil), carried out in nine large municipalities using the Wondfo lateral flow point-of-care test for immunoglobulin M and G antibodies against SARS-CoV-2 (https://en.wondfo.com.cn/product/wondfo-sars-cov-2-antibody-test-lateral-flow-method-2/). Before survey use, the assay underwent four validation studies with pooled estimates of sensitivity (84.8%; 95% confidence interval (CI) = 81.4-87.8%) and specificity (99.0%; 95% CI = 97.8-99.7%). We calculated that the seroprevalence was 0.048% (2/4,151; 95% CI = 0.006-0.174) on 11-13 April (round 1), 0.135% (6/4,460; 95% CI = 0.049-0.293%) on 25-27 April (round 2) and 0.222% (10/4,500; 95% CI = 0.107-0.408) on 9-11 May (round 3), with a significant upward trend over the course of the surveys. Of 37 family members of positive individuals, 17 (35%) were also positive. The epidemic is at an early stage in the state, and there is high compliance with social distancing, unlike in other parts of Brazil. Periodic survey rounds will continue to monitor trends until at least the end of September, and our population-based data will inform decisions on preventive policies and health system preparedness at the state level. |
| Databáze: | OpenAIRE |
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