Bacteria and Methanogens in the Human Microbiome: a Review of Syntrophic Interactions
| Autor: | Michel Drancourt, Maryam Tidjani Alou, Kenza Djemai |
|---|---|
| Přispěvatelé: | Microbes évolution phylogénie et infections (MEPHI), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
animal structures Methanogenesis Microorganism 030106 microbiology Soil Science Euryarchaeota 03 medical and health sciences Microbial ecology Syntrophy [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases medicine Humans Ecology Evolution Behavior and Systematics ComputingMilieux_MISCELLANEOUS Genetics Bacteria Ecology biology Microbiota Human microbiome biology.organism_classification medicine.disease Archaea [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology 030104 developmental biology Methane Dysbiosis |
| Zdroj: | Microbial Ecology Microbial Ecology, Springer Verlag, 2021, Early Access, ⟨10.1007/s00248-021-01796-7⟩ Microbial ecology Microbial ecology, 2022, Early Access, 83, pp.536-554. ⟨10.1007/s00248-021-01796-7⟩ |
| ISSN: | 0095-3628 1432-184X |
| Popis: | Methanogens are microorganisms belonging to the Archaea domain and represent the primary source of biotic methane. Methanogens encode a series of enzymes which can convert secondary substrates into methane following three major methanogenesis pathways. Initially recognized as environmental microorganisms, methanogens have more recently been acknowledged as host-associated microorganisms after their detection and initial isolation in ruminants in the 1950s. Methanogens have also been co-detected with bacteria in various pathological situations, bringing their role as pathogens into question. Here, we review reported associations between methanogens and bacteria in physiological and pathological situations in order to understand the metabolic interactions explaining these associations. To do so, we describe the origin of the metabolites used for methanogenesis and highlight the central role of methanogens in the syntrophic process during carbon cycling. We then focus on the metabolic abilities of co-detected bacterial species described in the literature and infer from their genomes the probable mechanisms of their association with methanogens. The syntrophic interactions between bacteria and methanogens are paramount to gut homeostasis. Therefore, any dysbiosis affecting methanogens might impact human health. Thus, the monitoring of methanogens may be used as a bio-indicator of dysbiosis. Moreover, new therapeutic approaches can be developed based on their administration as probiotics. We thus insist on the importance of investigating methanogens in clinical microbiology. |
| Databáze: | OpenAIRE |
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