A domestic porcine model for studying the effects of radiation on head and neck cancers
| Autor: | Danijela Vasiljevic, Günter Klima, Frank Kloss, Thomas Auberger, Robert Gassner, Volker Wenzel, Peter Lukas, Günter Lepperdinger, Sarvpreet Singh, Robert Stigler, Christoph Reinhold Arnold |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Under sedation Sedation Sus scrofa Treatment outcome Computed tomography Mandible Radiation Dosage Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine medicine Animals Radiology Nuclear Medicine and imaging Dentistry (miscellaneous) Head and neck medicine.diagnostic_test business.industry Standard treatment 030206 dentistry Surgery Sus scrofa domestica Disease Models Animal Clinical research Head and Neck Neoplasms 030220 oncology & carcinogenesis Radiology Oral Surgery medicine.symptom Tomography X-Ray Computed business |
| Zdroj: | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 123:536-543 |
| ISSN: | 2212-4403 |
| DOI: | 10.1016/j.oooo.2016.11.017 |
| Popis: | Background Radiation therapy (RT) of the head and neck region is often accompanied by serious side effects. Research in this area is needed to improve treatment outcomes and ameliorate therapy tolerance. Laboratory rodents are barely matching today's clinical standards in RT research. Yet domestic swine (Sus scrofa domestica) have previously proved suitable for various advanced tests in clinical research and training. We therefore investigated whether S. scrofa domestica is also appropriate for irradiation of the mandible. Study Design A common scheme for irradiation treatment of S. scrofa domestica mandibles in a split-mouth design was acquired by applying computed tomography (CT) scanning under sedation. Basing on close anatomic resemblance, a standard treatment plan comprising 2 opposed irradiation fields could be accomplished. Results RT was carried out in a clinical environment with 2 × 9 Gy. The resulting operating procedure facilitated complication-free sedation, transport, positioning, CT scanning, and effective irradiation. Conclusion Based on common standards applied for RT in humans, domestic pigs can be employed to progress RT clinical research. Due to their human-like anatomy, physiology, size, and weight, the swine model is expedient for advancing experimental RT of the head and neck area. |
| Databáze: | OpenAIRE |
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