Progression of Regional Microstructural Degeneration in Parkinson's Disease: A Multicenter Diffusion Tensor Imaging Study
| Autor: | Norbert Schuff, Eric D. Foster, I-Wei Wu, Duygu Tosun, Yu Zhang |
|---|---|
| Přispěvatelé: | Herholz, Karl |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Central Nervous System
0301 basic medicine Male Aging Pathology Parkinson's disease Physiology Image Processing lcsh:Medicine Neurodegenerative Nervous System Biochemistry Diagnostic Radiology 0302 clinical medicine Computer-Assisted Thalamus Materials Physics Medicine and Health Sciences Image Processing Computer-Assisted 2.1 Biological and endogenous factors Aetiology lcsh:Science Microstructure Cerebrospinal Fluid Brain Mapping Parkinson's Disease Movement Disorders Multidisciplinary Radiology and Imaging Physics Putamen Dopaminergic Brain Parkinson Disease Neurodegenerative Diseases Magnetic Resonance Imaging Body Fluids Substantia Nigra medicine.anatomical_structure Phenotype Diffusion Tensor Imaging Neurology Neurological Physical Sciences Cardiology Disease Progression Biomedical Imaging Female Anatomy Research Article medicine.medical_specialty Imaging Techniques General Science & Technology Brain Morphometry Materials Science Neuroimaging Substantia nigra Research and Analysis Methods White matter Midbrain 03 medical and health sciences Clinical Research Diagnostic Medicine Internal medicine Fractional anisotropy Acquired Cognitive Impairment medicine Humans Parkinson’s Progression Markers Initiative business.industry lcsh:R Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) Biology and Life Sciences medicine.disease Brain Disorders 030104 developmental biology nervous system Dementia lcsh:Q business 030217 neurology & neurosurgery Biomarkers Neuroscience Diffusion MRI Follow-Up Studies |
| Zdroj: | Zhang, Y; Wu, I-W; Tosun, D; Foster, E; Schuff, N; & In, PPM. (2016). Progression of Regional Microstructural Degeneration in Parkinson's Disease: A Multicenter Diffusion Tensor Imaging Study. PLOS ONE, 11(10). doi: 10.1371/journal.pone.0165540. UCSF: Retrieved from: http://www.escholarship.org/uc/item/1b91w50m PloS one, vol 11, iss 10 PLoS ONE, Vol 11, Iss 10, p e0165540 (2016) PLoS ONE |
| Popis: | This study aimed to identify the utility of diffusion tensor imaging (DTI) in measuring the regional distribution of abnormal microstructural progression in patients with Parkinson's disease who were enrolled in the Parkinson's progression marker initiative (PPMI). One hundred and twenty two de-novo PD patients (age = 60.5±9) and 50 healthy controls (age = 60.6±11) had DTI scans at baseline and 12.6±1 months later. Automated image processing included an intra-subject registration of all time points and an inter-subjects registration to a brain atlas. Annualized rates of DTI variations including fractional anisotropy (FA), radial (rD) and axial (aD) diffusivity were estimated in a total of 118 white matter and subcortical regions of interest. A mixed effects model framework was used to determine the degree to which DTI changes differed in PD relative to changes in healthy subjects. Significant DTI changes were also tested for correlations with changes in clinical measures, dopaminergic imaging and CSF biomarkers in PD patients. Compared to normal aging, PD was associated with higher rates of FA reduction, rD and aD increases predominantly in the substantia nigra, midbrain and thalamus. The highest rates of FA reduction involved the substantia nigra (3.6±1.4%/year from baseline, whereas the highest rates of increased diffusivity involved the thalamus (rD: 8.0±2.9%/year, aD: 4.0±1.5%/year). In PD patients, high DTI changes in the substantia nigra correlated with increasing dopaminergic deficits as well as with declining α-synuclein and total tau protein concentrations in cerebrospinal fluid. Increased DTI rates in the thalamus correlated with progressive decline in global cognition in PD. The results suggest that higher rates of regional microstructural degeneration are potential markers of PD progression. |
| Databáze: | OpenAIRE |
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