Effect of the consumption of hesperidin in orange juice on the transcriptomic profile of subjects with elevated blood pressure and stage 1 hypertension: A randomized controlled trial (CITRUS study)
| Autor: | M I Covas, Antoni Caimari, Rosa M. Valls, Cristina Domenech-Coca, Francesc Puiggròs, Josep M. del Bas, Judit Companys, Núria Canela, Anna Pedret, Lluís Arola, Elisabet Llauradó, Rosa Solà, Lorena Calderón-Pérez, Laura Pla-Pagà |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 3-Hydroxysteroid Dehydrogenases Down-Regulation Gene Expression Inflammation Blood Pressure Selenium-Binding Proteins Pharmacology Critical Care and Intensive Care Medicine Peripheral blood mononuclear cell law.invention Proinflammatory cytokine Hesperidin chemistry.chemical_compound Insulin resistance Randomized controlled trial Double-Blind Method law Medicine Humans Orange juice Nutrition and Dietetics business.industry Middle Aged medicine.disease Fruit and Vegetable Juices Mechanism of action chemistry Hypertension Leukocytes Mononuclear Female medicine.symptom business Transcriptome Citrus sinensis |
| Zdroj: | Clinical nutrition (Edinburgh, Scotland). 40(12) |
| ISSN: | 1532-1983 |
| Popis: | Summary Scope Hesperidin exerts cardiovascular beneficial effects, but its mechanisms of action remain undefined. In a previous study we demonstrated that a single dose and a 12-week treatment of hesperidin decreased systolic blood pressure. The aim of this study was to ascertain the action mechanisms of hesperidin consumption in subjects with elevated blood pressure or with stage 1 hypertension, by determining their transcriptomic profile after a single dose or a 12-week treatment. Methods and results For transcriptomic analysis, peripheral blood mononuclear cells were obtained from 37 subjects with elevated blood pressure and stage 1 hypertension from CITRUS study who were randomized to receive for 12 weeks: control drink (CD; n = 11), OJ (containing 345 mg of hesperidin; n = 15) or EOJ (containing 600 mg of hesperidin; n = 11). Before starting the 12-weeks treatment, a single dose study with a 6 h of follow-up in each group was performed. After the single dose consumption, EOJ versus OJ, downregulated DHRS9 gene which is related with insulin resistance. Compared to CD, 12-week treatment of EOJ downregulated 6 proinflammatory genes while after OJ consumption only 1 proinflammatory gene was downregulated. Moreover, 12-week treatment of EOJ versus OJ, downregulated acute coronary syndrome gene related (SELENBP1). Conclusion A single dose consumption of EOJ could protect from insulin resistance. Moreover, EOJ decrease the expression of proinflammatory genes after 12-week treatment providing a possible mechanism of action on inflammation pathway. |
| Databáze: | OpenAIRE |
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