Significant Association of Interleukin4 Intron 3 VNTR Polymorphism with Susceptibility to Gastric Cancer in a South Indian Population from Telangana
| Autor: | Ananthapur Venkateshwari, Adi Rakesh Kumar, Amar Chand Bhayal, Kondadasula Pandu Ranga Rao, Pratibha Nallari, Akka Jyothy, D. Krishnaveni |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Genotype lcsh:Medicine India Disease Biology medicine.disease_cause Polymorphism Single Nucleotide Young Adult Gene Frequency Stomach Neoplasms medicine Humans Genetic Predisposition to Disease Allele lcsh:Science Allele frequency Alleles Genetic Association Studies Aged Retrospective Studies Aged 80 and over Multidisciplinary lcsh:R Case-control study Cancer Middle Aged Helicobacter pylori medicine.disease biology.organism_classification Introns Case-Control Studies Immunology lcsh:Q Female Interleukin-4 Carcinogenesis Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 10, Iss 9, p e0138442 (2015) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0138442 |
| Popis: | Background Gastric cancer (GC) is the fifth most common malignancy and remains a considerable public health burden worldwide. Genetic variations in genes encoding cytokines and their receptors influence the intensity of the Helicobacter pylori associated inflammatory response, which may contribute to individual differences in the outcome and severity of the disease. Interleukin4 is a typical pleiotropic T helper 2 (Th2) cytokine and is a critical mediator of Th1/Th2 balance. It is involved in the regulation of inflammation-mediated carcinogenesis in human organs, including gastric cancer. Objective The present retrospective case control study was undertaken to evaluate the association of IL4 intron 3 VNTR polymorphism with the susceptibility to GC in a south Indian population from Telangana state. Materials and Methods A total of 182 patients with diagnosed GC and 326 randomly selected healthy controls were enrolled in the present study. Genomic DNA was extracted from peripheral leukocytes and genotyping was determined by PCR-based assay. Association between genotypes and gastric cancer was examined by unconditional logistic regression analysis. Result The variant 3R/2R and 2R/2R genotypes of IL4 exon3 VNTR polymorphism had about 1.9 fold and 3fold increased GC risk, respectively, when compared with 3R/3R genotype [3R/2R vs. 3R/3R: adjusted odds ratio (AOR) = 1.90, 95% confidence interval (CI) = 1.23–2.95 P = 0.004 and 2R/2R vs. 3R/3R: AOR (95%CI) = 2.96 (1.29–6.82), P = 0.011]. Furthermore, a significant increased risk of GC was found for the 2R allele carriers (3R/2R + 2R/2R) compared with the 3R/3R genotype (AOR (95%CI) = 2.04 (1.35–3.10), P = |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|