Antigen-Presenting Cells and their Fcγ and Toll-Like Receptors: Leading Suspects in Autoimmunity
| Autor: | Wim B. van den Berg, Lenny van Bon, Kim C. M. Santegoets, Mark H. Wenink |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
business.industry
Pathogen-associated molecular pattern medicine.disease_cause Infection and autoimmunity Auto-immunity transplantation and immunotherapy [NCMLS 1] Autoimmunity Pathogenesis medicine.anatomical_structure Immune system Immunology Medicine skin and connective tissue diseases business Antigen-presenting cell Receptor GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) B cell Intracellular |
| Zdroj: | The Open Arthritis Journal, 3, 37-46 The Open Arthritis Journal, 3, pp. 37-46 |
| ISSN: | 1876-5394 |
| DOI: | 10.2174/1876539401003010037 |
| Popis: | Antigen-presenting cells (APCs) play an important role in the development of autoimmune diseases. These cells recognize pathogen associated molecular patterns but also endogenously produced ligands through toll-like receptors (TLRs). Aberrant activation of these receptors and the following intracellular signaling pathways can induce the deleteri- ous production of pro-inflammatory cytokines. In genetically predisposed individuals this might lead to a breach in toler- ance and eventually autoimmunity. IgG and IgG immune complexes (ICs), which are abundantly present in autoimmune diseases like systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and systemic sclerosis (SSc) are recognized by APCs via Fc gamma receptors (Fc Rs) and can also modulate their activation state. Upon their uptake specific antigens present in ICs are capable of stimulating APCs via their intracellular TLRs, increasing their capability to induce (autoreac- tive) T and B cell responses. This underscores their likely role in the generation and maintenance of autoimmunity. By fo- cusing on three autoimmune diseases, SLE, RA and SSc, we will illustrate the importance of TLRs and Fc Rs in the pathogenesis of autoimmune diseases. |
| Databáze: | OpenAIRE |
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