Hereditary motor and sensory neuropathies and hereditary spastic paraplegia: A magnetic stimulation study
| Autor: | D. Claus, H. M. Waddy, P. K. Thomas, N. M. F. Murray, A. E. Harding |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Adolescent Hereditary spastic paraplegia Neural Conduction Sensory system Stimulation Magnetics Degenerative disease Electroneuronography medicine Humans Aged Leg Spastic Paraplegia Hereditary business.industry Peroneal muscular atrophy Middle Aged medicine.disease Muscular Atrophy Neurology Female Neurology (clinical) Hereditary Sensory and Motor Neuropathy business Hereditary motor and sensory neuropathy Neuroscience |
| Zdroj: | Annals of Neurology. 28:43-49 |
| ISSN: | 1531-8249 0364-5134 |
| DOI: | 10.1002/ana.410280109 |
| Popis: | Central motor conduction to the small hand muscles was investigated in 59 patients with peroneal muscular atrophy and hereditary spastic paraplegia (HSP) by using transcranial magnetic brain stimulation. These comprised 20 patients with type I hereditary motor and sensory neuropathy (HMSN I), 15 with type II (HMSN II), 4 with HMSN I and 10 with HMSN II with associated pyramidal features, and 10 with the "pure" form of HSP. Central motor conduction was usually normal in HMSN I, HMSN II, and HSP. In HMSN I with pyramidal signs, central motor conduction time was greatly prolonged bilaterally. This result may reflect an associated involvement of the central motor pathways in these patients. In HMSN II with accompanying pyramidal features, 6 of the 10 patients had abnormal central motor conduction, although conduction times were only slightly prolonged, suggesting a different pathophysiological pattern. |
| Databáze: | OpenAIRE |
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