Prognostic Value of FDG PET/CT in Patients With Neuroendocrine Carcinoma of the Uterine Cervix
| Autor: | Yuanyuan Jiang, Zhaohui Zhu, Wuying Cheng, Fang Li, Guozhu Hou |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty Uterine Cervical Neoplasms Fluorodeoxyglucose F18 Positron Emission Tomography Computed Tomography Internal medicine Statistical significance Carcinoma Humans Medicine Radiology Nuclear Medicine and imaging In patient Stage (cooking) Retrospective Studies Univariate analysis business.industry Proportional hazards model Retrospective cohort study General Medicine Prognosis medicine.disease Carcinoma Neuroendocrine Tumor Burden Female Fdg pet ct Radiopharmaceuticals business Glycolysis |
| Zdroj: | Clinical Nuclear Medicine. 46:971-976 |
| ISSN: | 1536-0229 0363-9762 |
| DOI: | 10.1097/rlu.0000000000003909 |
| Popis: | We evaluated the prognostic value of metabolic parameters measured on pretreatment FDG PET/CT in patients with cervical neuroendocrine carcinomas (NECs).A total of 22 patients with cervical NECs who underwent pretreatment FDG PET/CT were retrospectively reviewed. The SUVmax, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of the primary lesion were measured. The associations between prognostic factors and progression-free survival (PFS) and overall survival (OS) were investigated using the Kaplan-Meier method, log-rank test, and univariate and multivariate Cox proportional hazards model.Of the 22 patients, 12 developed disease progression, and 5 died during the follow-up period. Univariate analyses revealed that MTV, TLG, and the International Federation of Gynecology and Obstetrics stage were significantly associated with PFS (all P0.05), whereas SUVmax did not show a significant correlation with PFS. Kaplan-Meier survival curves revealed that patients with MTV31.9 cm3 (log-rank, P0.001), TLG154.3 (log-rank, P0.001), and higher International Federation of Gynecology and Obstetrics stage (log-rank, P = 0.026) had significantly shorter PFS. In the multivariate analyses, MTV (P = 0.017; hazard ratio [HR], 7.298; 95% confidence interval [CI], 1.427-37.316) and TLG (P = 0.003; HR, 15.175; 95% CI, 2.470-93.244) were independent prognostic factors, whereas for OS, the univariate analysis revealed that only TLG154.3 showed statistical significance (P = 0.043; HR, 9.821; 95% CI, 1.080-89.290).Metabolic tumor volume and TLG on FDG PET/CT were the significant prognostic factors of PFS in patients with cervical NECs. Patients with high MTV and TLG had worse clinical outcomes. In addition, TLG may also be a predictor of OS. |
| Databáze: | OpenAIRE |
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