Growth inhibition of human salivary gland tumor cells by introduction of progesterone (Pg) receptor and Pg treatment
| Autor: | Pierre-Yves Desprez, Hiroyuki Hamakawa, A. Onishi, Tomohide Yoshimura, S. Liu, Satoru Shintani, Tomoki Sumida |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Cancer Research
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Mammary gland Breast Neoplasms Biology Inhibitory postsynaptic potential Surgical pathology chemistry.chemical_compound Endocrinology Cell Line Tumor Internal medicine medicine Humans Neoplasm Invasiveness Receptor Telomerase Progesterone Reverse Transcriptase Polymerase Chain Reaction Cell Cycle Female sex Flow Cytometry Salivary Gland Neoplasms Steroid hormone Salivary gland tumor medicine.anatomical_structure Oncology chemistry Female Growth inhibition Receptors Progesterone Cell Division |
| Zdroj: | Endocrine Related Cancer. 14:1107-1116 |
| ISSN: | 1479-6821 1351-0088 |
| DOI: | 10.1677/erc.1.01253 |
| Popis: | Cancer of the salivary gland is one of the common cancers in the head and the neck regions. This type of cancer develops in the minor and the major salivary glands, and it sometimes metastasizes to other organs, particularly the lung. Morphologic mimicry and similarity in the expression of steroid hormone receptors between salivary gland tumors (SGTs) and breast tumors are well-known phenomena and are occasionally debated in the field of surgical pathology. Progesterone (Pg), one of the female sex steroid hormone, is intimately involved in the development of the mammary gland. Further, it is believed that Pg plays a role in breast cancer progression. However, little is known regarding its role in SGTs. In this study, we used ACCM, a human adenoid cystic carcinoma cell line established from the salivary gland, in order to clarify the role of the Pg receptor (PR) on cell proliferation. No effect of Pg on cell proliferation was observed in the PR-deficient aggressive ACCM cells. However, after introducing PR into the ACCM cells, Pg markedly inhibited the proliferative activity of the cells. This inhibitory effect on cell proliferation was accompanied by p21 upregulation, and Id1 and c-myc downregulation. Moreover, Pg-treated PR transfectants showed significant morphological change; they appeared more flattened and spread out when compared with the ethanol-treated control cells. Our results provided significant insights into the mechanism of suppression of the proliferative property of the cells via the function of PR, and suggested that PR reintroduction therapy might be a viable method of inhibiting human SGT progression. |
| Databáze: | OpenAIRE |
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