Postnatal maturation of carotid body and type I cell chemoreception in the rat
| Autor: | Marshall H. Montrose, John L. Carroll, Laura M. Sterni, M. J. Wasicko, O. S. Bamford |
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| Rok vydání: | 1999 |
| Předmět: |
Pulmonary and Respiratory Medicine
Aging medicine.medical_specialty Chemoreceptor Physiology Cell Biology Calcium in biology Physiology (medical) Internal medicine medicine Animals Carotid Body Fetus Cell Biology Carbon Dioxide Hydrogen-Ion Concentration Cell Hypoxia Chemoreceptor Cells Rats Electrophysiology Oxygen medicine.anatomical_structure Endocrinology Animals Newborn Microscopy Fluorescence Calcium Carotid body Type i cells Intracellular |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1522-1504 1040-0605 |
| DOI: | 10.1152/ajplung.1999.276.5.l875 |
| Popis: | The site of postnatal maturation of carotid body chemoreception is unclear. To test the hypothesis that maturation occurs synchronously in type I cells and the whole carotid body, the development of changes in the intracellular Ca2+concentration responses to hypoxia, CO2, and combined challenges was studied with fluorescence microscopy in type I cells and compared with the development of carotid sinus nerve (CSN) responses recorded in vitro from term fetal to 3-wk animals. Type I cell responses to all challenges increased between 1 and 8 days and then remained constant, with no multiplicative O2-CO2interaction at any age. The CSN response to hypoxia also matured by 8 days, but CSN responses to CO2did not change significantly with age. Multiplicative O2-CO2interaction occurred in the CSN response at 2–3 wk but not in younger groups. We conclude that type I cell maturation underlies maturation of the CSN response to hypoxia. However, because development of responses to CO2and combined hypoxia-CO2challenges differed between type I cells and the CSN, responses to these stimuli must mature at other, unidentified sites within the developing carotid body. |
| Databáze: | OpenAIRE |
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