Heavy metal pollution and co-selection for antibiotic resistance: A microbial palaeontology approach

Autor: Michiel Vos, Paul O'Neill, M.G. Hansen, Richard T. Jones, Kristian K. Brandt, Pawel Sierocinski, Peter G. Appleby, A.W. Dickinson, G.T. Piliposian, Ann Power, Britt Koskella
Rok vydání: 2019
Předmět:
Geologic Sediments
History
Cefotaxime
010504 meteorology & atmospheric sciences
Antibiotics
Drug Resistance
010501 environmental sciences
Antimicrobial resistance
01 natural sciences
Sediment archive
Microbial
lcsh:Environmental sciences
General Environmental Science
lcsh:GE1-350
Microbiota
Bacterial
Drug Resistance
Microbial
History
19th Century
Heavy
21st Century
Anti-Bacterial Agents
20th Century
Infectious Diseases
Metals
5.1 Pharmaceuticals
Environmental Pollutants
Development of treatments and therapeutic interventions
Water Microbiology
Infection
Environmental Monitoring
medicine.drug
medicine.drug_class
chemistry.chemical_element
Zinc
Biology
History
21st Century
Co-selection
Paleontology
Antibiotic resistance
Metals
Heavy
medicine
Cross-resistance
Ponds
0105 earth and related environmental sciences
19th Century
Bacteria
Water Pollution
Metal pollution
History
20th Century
biology.organism_classification
United Kingdom
Genes
chemistry
Microbial population biology
Genes
Bacterial
Trimethoprim Resistance
Environmental Sciences
Zdroj: Environment International
Environment International, Vol 132, Iss, Pp-(2019)
Dickinson, A W, Power, A, Hansen, M G, Brandt, K K, Piliposian, G, Appleby, P, O'Neill, P A, Jones, R T, Sierocinski, P, Koskella, B & Vos, M 2019, ' Heavy metal pollution and co-selection for antibiotic resistance : A microbial palaeontology approach ', Environment International, vol. 132, 105117, pp. 1-10 . https://doi.org/10.1016/j.envint.2019.105117
ISSN: 0160-4120
DOI: 10.1016/j.envint.2019.105117
Popis: Frequent and persistent heavy metal pollution has profound effects on the composition and activity of microbial communities. Heavy metals select for metal resistance but can also co-select for resistance to antibiotics, which is a global health concern. We here document metal concentration, metal resistance and antibiotic resistance along a sediment archive from a pond in the North West of the United Kingdom covering over a century of anthropogenic pollution. We specifically focus on zinc, as it is a ubiquitous and toxic metal contaminant known to co-select for antibiotic resistance, to assess the impact of temporal variation in heavy metal pollution on microbial community diversity and to quantify the selection effects of differential heavy metal exposure on antibiotic resistance. Zinc concentration and bioavailability was found to vary over the core, likely reflecting increased industrialisation around the middle of the 20th century. Zinc concentration had a significant effect on bacterial community composition, as revealed by a positive correlation between the level of zinc tolerance in culturable bacteria and zinc concentration. The proportion of zinc resistant isolates was also positively correlated with resistance to three clinically relevant antibiotics (oxacillin, cefotaxime and trimethoprim). The abundance of the class 1 integron-integrase gene, intI1, marker for anthropogenic pollutants correlated with the prevalence of zinc- and cefotaxime resistance but not with oxacillin and trimethoprim resistance. Our microbial palaeontology approach reveals that metal-contaminated sediments from depths that pre-date the use of antibiotics were enriched in antibiotic resistant bacteria, demonstrating the pervasive effects of metal-antibiotic co-selection in the environment. Keywords: Metal pollution, Antimicrobial resistance, Sediment archive, Cross-resistance, Co-selection
Databáze: OpenAIRE
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