5,6,7 trihydroxy flavone armoured neurodegeneration caused by Quinolinic acid induced huntington’s like disease in rat striatum - reinstating the level of brain neurotrophins with special reference to cognitive-socio behaviour, biochemical and histopathological aspects
| Autor: | Bhagyalakshmi Purushothaman, Thangarajan Sumathi |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Male
Excitotoxicity Striatum Pharmacology medicine.disease_cause Neuroprotection chemistry.chemical_compound Cognition medicine Animals Neurotoxin Nerve Growth Factors Rats Wistar biology General Neuroscience Neurodegeneration Brain General Medicine Quinolinic Acid Flavones biology.organism_classification medicine.disease Corpus Striatum Rats Baicalein Disease Models Animal Huntington Disease chemistry Neuroinflammatory Diseases Scutellaria baicalensis Quinolinic acid |
| Zdroj: | Neuroscience Research. 174:25-35 |
| ISSN: | 0168-0102 |
| Popis: | Huntington Disease (HD), a predominant Neurodegenerative Disorder which might be induced by endogenous neurotoxin called Quinolinic Acid (QA), an N-methyl-D aspartate receptor (NMDAR) agonist, the bilaterally intrastriatal administration (200 nm/2 μL of saline) offers rise to the toxic events like neuronal death, neuroinflammation by inflicting excitotoxicity and oxidative stress in the striatum of male Wistar rats by exhibiting the behavioural changes which was accessed by rotarod, open field analysis. In this study, the neuropharmacological effect of Baicalein (BC) against QA induced HD was evaluated. Baicalein (BC), scientifically 5,6,7 trihydroxy flavone present naturally in the edible plants like Scutellaria baicalensis and Oroxylum indicum possess a better neuroprotective effect in the dosage of 10 mg/kg and 30 mg/kg intraperitoneally in the striatum of HD induced rats. This study proved that BC is efficient to revive the level of enzymaticnon-enzymatic antioxidants and mitochondrial complexes by decreasing the number of inflammatory mediators such as MDA, protein carbonyls and Nitric Oxide at the significance of P 0.01 and restores the amount of BDNF and GDNF thereby preventing the neurophysiological changes which were analysed by haematoxylineosin staining. Thus finally, the protective effect of Baicalein displays the up-gradation of psychological and behavioural changes induced by QA. |
| Databáze: | OpenAIRE |
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