Explication of the roles of prostate health index (PHI) and urokinase plasminogen activator (uPA) as diagnostic and predictor tools for prostate cancer in equivocal PSA range of 4–10 ng/mL
| Autor: | Hala F. M. Kamel, Anmar M. Nassir |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
0301 basic medicine Oncology medicine.medical_specialty Prostate cancer -Urokinase plasminogen activator- prostate health index- Gleason score urologic and male genital diseases 01 natural sciences Article 03 medical and health sciences Health index Prostate cancer Prostate Internal medicine medicine lcsh:QH301-705.5 Pathological Cause of death business.industry Urokinase Plasminogen Activator Area under the curve Hyperplasia medicine.disease 030104 developmental biology medicine.anatomical_structure lcsh:Biology (General) General Agricultural and Biological Sciences business 010606 plant biology & botany |
| Zdroj: | Saudi Journal of Biological Sciences Saudi Journal of Biological Sciences, Vol 27, Iss 8, Pp 1975-1984 (2020) |
| ISSN: | 1319-562X |
| DOI: | 10.1016/j.sjbs.2020.04.004 |
| Popis: | Background Prostate cancer (PCa) is one of the most commonly encountered cancers and the leading cause of death worldwide. Currently used biomarkers accounts difficulties in discriminating benign from malignant cases or predicting outcome, so investigating new biomarkers performance is needed. Objectives Assessment of diagnostic and predictor roles of prostate health index (PHI) and urokinase plasminogen activator (uPA) in PCa. Methods 194 males with initial tPSA of 4–10 ng/mL were categorized into three groups: PCa, benign prostatic hyperplasia (BPH) and healthy control. Serum levels of tPSA, fPSA, p2PSA, and uPA were performed by ELISA with calculation of PHI as (p2PSA/fPSA) × √PSA. Results PHI and uPA were significantly higher in PCa patients relevant to BPH and healthy control (p ≤ 0.001). Both markers outperformed all assessed biomarkers and showed the highest area under the curve (AUC) in ROC curve analysis. Both were significantly higher in PCa patients with {Gleason score ≥ 7, late stages (cT2b,c; T3), LN extension and distant metastasis}relative to their counterparts. Additionally, PHI and uPA and were independent predictors of distant metastasis and Gleason score ≥ 7, while PHI was predictor of LN invasion (β = 0.25, p = 0.004). Conclusion PHI and uPA would be of potential value in discriminating between PCa, BPH and healthy men in addition, both are promising as independent predictors of adverse pathological features. |
| Databáze: | OpenAIRE |
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