Aggressive resection of retroperitoneal sarcoma is superior to simple excision: An animal study using a novel model for retroperitoneal sarcoma
| Autor: | Alexander Shtabsky, Amir Szold, Alexander Tsivian, Dina Lev-Chelouche, Mordechai Gutman, Josephine Issakov, A. Ami Sidi |
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| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Aggressive surgery Resection Random Allocation medicine Animals Retroperitoneal sarcoma Animal study Retroperitoneal Neoplasms Laparoscopy Fibrosarcoma Retrospective Studies medicine.diagnostic_test business.industry Sarcoma General Medicine medicine.disease Rats Surgery Survival Rate Disease Models Animal medicine.anatomical_structure Oncology Evaluation Studies as Topic Abdomen Neoplasm Recurrence Local business Neoplasm Transplantation |
| Zdroj: | Journal of Surgical Oncology. 81:144-147 |
| ISSN: | 1096-9098 0022-4790 |
| Popis: | Background and Objectives Retroperitoneal sarcomas constitute a difficult management problem. The need for, and extent of, aggressive surgery continues to be debated. The aim of our study was to compare the impact of radical en bloc resection of retroperitoneal sarcoma with complete resection of the tumor alone in a rat model. Methods Under laparoscopic guidance, a fibrosarcoma cell line suspension was injected into the left paranephric space of a rat, resulting in the development of a macroscopic retroperitoneal tumor. Ten days after inoculation, 50 rats were randomized into three groups: (1) local resection, (2) radical resection, and (3) follow-up only. Groups 1 and 2 were further randomized for sacrifice 1 month after surgery or were followed up for 2 months. Results Local recurrence: 46% of group 1, while none in group 2 developed local recurrence during the same follow-up period (P = 0.02). Survival: 33% of group 1 were alive after 2 months, as compared with 54.5% of group 2. (P = 0.04). All rats in the control group died within |
| Databáze: | OpenAIRE |
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