Delayed and Precocious Puberty: Genetic Underpinnings and Treatments
| Autor: | Anisha Gohil, Erica A. Eugster |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Delayed puberty
Peripheral Precocious Puberty Adolescent Endocrinology Diabetes and Metabolism Central precocious puberty Puberty Precocious Physiology 030209 endocrinology & metabolism Article 03 medical and health sciences 0302 clinical medicine Endocrinology Hypergonadotropic hypogonadism Hypogonadotropic hypogonadism Humans Medicine Precocious puberty Child Puberty Delayed business.industry Hypogonadism Sex chromosomal abnormalities medicine.disease 030220 oncology & carcinogenesis Primary treatment medicine.symptom business |
| Zdroj: | Endocrinol Metab Clin North Am |
| ISSN: | 0889-8529 |
| DOI: | 10.1016/j.ecl.2020.08.002 |
| Popis: | Delayed puberty may signify a common variation of normal development, or indicate the presence of a pathologic process. Constitutional delay of growth and puberty is a strongly familial type of developmental pattern and accounts for the vast majority of children who are "late bloomers." Individuals with sex chromosomal abnormalities frequently have hypergonadotropic hypogonadism. There are currently 4 known monogenic causes of central precocious puberty. The primary treatment goal in children with hypogonadism is to mimic normal pubertal progression, while the primary aims for the management of precocious puberty are preservation of height potential and prevention of further pubertal development. |
| Databáze: | OpenAIRE |
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