Glycosaminoglycans: Anticoagulant and Nonanticoagulant Actions: A Short History of Symposia Held at Villa Vigoni
| Autor: | A. Naggi, Sandra Krämer, Job Harenberg, G. Torri, B. Casu, Roland Krämer |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
business.industry
medicine.drug_class education Anticoagulant Editor in chief Anticoagulants Thrombosis Hematology Congresses as Topic Heparin Low-Molecular-Weight History 20th Century History 21st Century humanities Liver tissue Immunology Humans Medicine In patient Tumor growth Cardiology and Cardiovascular Medicine business Classics Glycosaminoglycans Research data |
| Zdroj: | Seminars in Thrombosis and Hemostasis. 40:831-836 |
| ISSN: | 1098-9064 0094-6176 |
| DOI: | 10.1055/s-0034-1395152 |
| Popis: | Heparin, a sulfated polysaccharide belonging to the family of glycosaminoglycans, was discovered in the beginning of the 20th century and was initially identified as a procoagulant isolated from liver tissue. After the first application in patients approximately 30 years later, further purification identified the major as well as minor, but important, component units of the complex chain mixtures constituting heparin and the multiplex actions became a scientific challenge recently. A series of “Glycosaminoglycan symposium—anticoagulant and nonanticoagulant actions” developed over the past 20 years and focused on this topic has published research data in three issues of Seminars in Thrombosis & Hemostasis and in several other international scientific journals. The latest developments on the methods of analysis, the synthesis, the degradation by heparanases and the nonanticoagulant effects in tumor growth, in anti-inflammatory diseases, and in Alzheimer diseases as presented in the 21st symposium are summarized in the present overview on the occasion of the 40th anniversary of the journal with special reference to the journal's founding Editor in Chief, Eberhard F. Mammen. |
| Databáze: | OpenAIRE |
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