Comparison of analgesic activities of aconitine in different mice pain models

Autor: Qiuju Huang, Zhongqiu Liu, Xiaoxiao Qi, Yanmin Zhang, Linlin Lu, Jiahao Chen, Ying Wang, Jian-Hua Deng, Jiada Han, Dawei Wang, Feng Qian, Elaine Lai-Han Leung
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Nociception
Hot Temperature
Freund's Adjuvant
Social Sciences
Pharmacology
Mice
chemistry.chemical_compound
0302 clinical medicine
Medicine and Health Sciences
Edema
Psychology
Immune Response
Acetic Acid
Analgesics
Aspirin
Multidisciplinary
Pharmaceutics
Chemistry
Drugs
Hyperalgesia
030220 oncology & carcinogenesis
Physical Sciences
Neuropathic pain
Medicine
Female
Sensory Perception
medicine.symptom
Research Article
medicine.drug
Pain Threshold
Drug Administration
Aconitine
Science
Immunology
Analgesic
Pain
03 medical and health sciences
Signs and Symptoms
Drug Therapy
Formaldehyde
Threshold of pain
medicine
Animals
Pain Management
Neuropathic Pain
Inflammation
Chemical Compounds
Cognitive Psychology
Biology and Life Sciences
Visceral pain
Mice
Inbred C57BL
Disease Models
Animal
Cognitive Science
Perception
Clinical Medicine
Acids
030217 neurology & neurosurgery
Neuroscience
Zdroj: PLoS ONE, Vol 16, Iss 4, p e0249276 (2021)
PLoS ONE
ISSN: 1932-6203
Popis: Aconitine (AC) is the primary bioactive and secondary metabolite alkaloidin of Aconitum species which is accounted for more than 60% of the total diester-diterpenoid alkaloids in Aconite. To evaluate the analgesic effects of AC, 4 different pain models including hot plate assay, acetic acid writhing assay, formalin and CFA induced pain models were adopted in this study. In hot plate experiment, AC treatment at concentration of 0.3 mg/kg and 0.9 mg/kg improved the pain thresholds of mice similar to the positive drug aspirin at the concentration of 200 mg/kg (17.12% and 20.27% VS 19.21%). In acetic acid writhing experiment, AC significantly reduced the number of mice writhing events caused by acetic acid, and the inhibition rates were 68% and 76%. These results demonstrated that AC treatment revealed significant analgesic effects in both acute thermal stimulus pain model and chemically-induced visceral pain model. The biphasic nociceptive responses induced by formalin were significantly inhibited after AC treatment for 1h or 2h. The inhibition rates were 33.23% and 20.25% of AC treatment for 1h at 0.3 mg/kg and 0.9 mg/kg in phase I. In phase II, the inhibition rates of AC and aspirin were 36.08%, 32.48% and 48.82% respectively, which means AC showed similar analgesic effect to non-steroidal anti-inflammatory compounds. In the chronic CFA-induced nociception model, AC treatment also improved mice pain threshold to 131.33% at 0.3 mg/kg, which was similar to aspirin group (152.03%). Above all, our results verified that AC had obviously analgesic effects in different mice pain models.
Databáze: OpenAIRE
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