The effect of substance(s) associated with malarial parasites on C3b inactivator
Autor: | A.A. Okerengwo, A.I.O. Williams, B.O. Osunkoya |
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Rok vydání: | 1987 |
Předmět: |
Antigen-Antibody Complex
Erythrocytes Antigens Protozoan chemical and pharmacologic phenomena Complement factor I Biology Microbiology Plasmodium malariae Immune system Antigen Complement C3b Inactivator Proteins medicine Animals Humans Malarial parasites Kidney Public Health Environmental and Occupational Health Immune adherence General Medicine Immune Adherence Reaction Infectious Diseases medicine.anatomical_structure Immunology biology.protein Parasitology Antibody |
Zdroj: | Transactions of the Royal Society of Tropical Medicine and Hygiene. 81:881-884 |
ISSN: | 0035-9203 |
DOI: | 10.1016/0035-9203(87)90335-x |
Popis: | The effects of a substance or substances associated with malarial parasites on the inhibitory role of C3b inactivator in immune adherence were investigated. The test system involved adherence of immune complexes of complement-bearing sheep erythrocytes and rabbit antibody, using human group O erythrocytes and human renal glomerular tissues as indicators. Malarial antigen and other soluble by-products of the malarial parasites, presumably present in spent culture medium, did not interfere with the inhibitory role of C3b inactivator. However, malarial pigment, both crude and purified, enhanced immune adherence in the presence of C3b inactivator. It is suggested that malarial pigment, by inhibiting the action of C3b inactivator, may play a significant role in the immunopathogenesis of renal lesions associated with malarial infections. |
Databáze: | OpenAIRE |
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