Atorvastatin and clopidogrel interfere with photosensitization in vitro
| Autor: | Dong Kun Lee, Soo Min Shon, Dong-Eog Kim, Yongdoo Choi, Jin Eok Park, Dawid Schellingerhout |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Porphyrins
Ticlopidine Light medicine.medical_treatment Atorvastatin Photodynamic therapy Pharmacology Cathepsin B Cell Line Polyethylene Glycols Mice Neoplasms medicine Macrophage Animals Humans Photosensitizer Polylysine Pyrroles Physical and Theoretical Chemistry chemistry.chemical_classification Reactive oxygen species Photosensitizing Agents Aspirin business.industry Anticholesteremic Agents Macrophages Clopidogrel In vitro chemistry Photochemotherapy Heptanoic Acids Cancer cell business medicine.drug |
| Zdroj: | Photochemicalphotobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 10(10) |
| ISSN: | 1474-9092 |
| Popis: | Photodynamic therapy (PDT) has been used to eliminate undesired cells by using a combination of photosensitizers and light illumination to generate reactive oxygen species. There is great interest in applying PDT to atherosclerosis; preferential destruction of pro-inflammatory macrophages in atheromata might attenuate plaque growth or rupture-prone vulnerability. Here, we report on a previously unknown interaction between cardiovascular drugs that are commonly prescribed for atherosclerosis patients and the cytolytic effects of photodynamic therapy using Cathepsin B activatable photosensitizer L-SR15 on murine macrophage Raw 264.7 cells in culture. Atorvastatin and clopidogrel significantly interfered with in vitro photosensitization effect while aspirin did this to a lesser extent; these drugs did not change the efficiency of cellular uptake of L-SR15 after in vitro photosensitization. A photosensitization interference effect of atorvastatin and clopidogrel was also observed when using a conventional photosensitizer free Ce6 or NCI-H1299 cancer cells. Considering the clinical implications of PDT, our study merits further investigation in clinical settings as well as in animal models. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink