Impact of I/D polymorphism of angiotensin-converting enzyme (ACE) gene on myocardial infarction susceptibility among young Moroccan patients

Autor: Meriem Haboub, Sellama Nadifi, Brehima Diakite, Wiam Hmimech, Farah Korchi, Dalila Baghdadi, Hind Tahri Joutey Hassani Idrissi, Hind Hassani Idrissi, Rachida Habbal
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
Myocardial Infarction
lcsh:Medicine
030204 cardiovascular system & hematology
Gastroenterology
0302 clinical medicine
Gene Frequency
INDEL Mutation
Risk Factors
Genotype
lcsh:QH301-705.5
biology
General Medicine
Middle Aged
Morocco
Research Note
Female
Adult
Myocardial infarction (MI)
medicine.medical_specialty
Peptidyl-Dipeptidase A
Moroccan patients
General Biochemistry
Genetics and Molecular Biology

03 medical and health sciences
Internal medicine
Genetic susceptibility
medicine
Genetic predisposition
Humans
Genetic Predisposition to Disease
Allele
lcsh:Science (General)
Allele frequency
Alleles
Polymorphism
Genetic

Insertion/deletion (I/D) ACE (angiotensin converting enzyme) gene polymorphism
business.industry
lcsh:R
Wild type
Case-control study
Angiotensin-converting enzyme
030104 developmental biology
lcsh:Biology (General)
Case-Control Studies
biology.protein
Gene polymorphism
business
lcsh:Q1-390
Zdroj: BMC Research Notes, Vol 10, Iss 1, Pp 1-6 (2017)
BMC Research Notes
ISSN: 1756-0500
DOI: 10.1186/s13104-017-3039-1
Popis: Objective Our case–control study aimed to access the potential association of insertion/deletion (I/D) ACE (angiotensin converting enzyme) gene polymorphism with myocardial infarction (MI) risk of occurrence among a sample of Moroccan patients, especially young ones. Results Distribution of I/D ACE gene variant among cases vs controls, showed that healthy controls carried out higher frequency of wild type allele I compared to cases (23.5% vs 21.79% respectively), when cases were carrying higher frequency of mutant allele D (78.21% vs 76.5% for controls). Patients were-after this- divided into two groups of 55 years of age, to investigate whether or not younger patients carried out higher frequency of the mutant allele D, than older ones. As expected
Databáze: OpenAIRE