Effects of low-level laser therapy (LLLT) and diclofenac (topical and intramuscular) as single and combined therapy in experimental model of controlled muscle strain in rats
| Autor: | Rodrigo Álvaro Brandão Lopes-Martins, Rodrigo Labat Marcos, Maria Carla Petrellis, Ernesto Cesar Pinto Leal-Junior, Gilberto De Nucci, Maria Helena Catelli de Carvalho, Rodrigo Leal de Paiva Carvalho |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Diclofenac Soft Tissue Injuries medicine.medical_treatment Gene Expression Muscle damage Biochemistry FARMACOLOGIA Injections Intramuscular Dinoprostone Tibialis anterior muscle medicine Combined Modality Therapy Animals Physical and Theoretical Chemistry Prostaglandin E2 Low-Level Light Therapy Rats Wistar Muscle Skeletal Low level laser therapy Experimental model business.industry Anti-Inflammatory Agents Non-Steroidal Membrane Proteins General Medicine Rats Cyclooxygenase 2 Anesthesia Cyclooxygenase 1 Sprains and Strains Combined therapy business Biomarkers medicine.drug |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1751-1097 |
| Popis: | Muscle injuries represent ca 30% of sports injuries and excessive stretching of muscle causes more than 90% of injuries. Currently the most used treatments are nonsteroidal anti-inflammatory drugs (NSAIDs), however, in last years, low-level laser therapy (LLLT) is becoming an interesting therapeutic modality. The aim of this study was to evaluate the effect of single and combined therapies (LLLT, topical application of diclofenac and intramuscular diclofenac) on functional and biochemical aspects in an experimental model of controlled muscle strain in rats. Muscle strain was induced by overloading tibialis anterior muscle of rats. Injured groups received either no treatment, or a single treatment with topical or intramuscular diclofenac (TD and ID), or LLLT (3 J, 810 nm, 100 mW) 1 h after injury. Walking track analysis was the functional outcome and biochemical analyses included mRNA expression of COX-1 and COX-2 and blood levels of prostaglandin E2 (PGE2). All treatments significantly decreased COX-1 and COX-2 gene expression compared with injury group (P |
| Databáze: | OpenAIRE |
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