A Pediatric Bone Mass Scan has Poor Ability to Predict Peak Bone Mass: An 11-Year Prospective Study in 121 Children
| Autor: | Christian Buttazzoni, Caroline Karlsson, Magnus Karlsson, Björn E. Rosengren, Jan-Åke Nilsson, Magnus Dencker |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
musculoskeletal diseases
Peak bone mass Longitudinal study medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Population Young Adult Endocrinology Absorptiometry Photon Bone Density Medicine Humans Orthopedics and Sports Medicine Longitudinal Studies Prospective Studies Young adult Prospective cohort study education Child Femoral neck Bone mineral education.field_of_study Bone Development Lumbar Vertebrae business.industry Femur Neck medicine.anatomical_structure Quartile Radiology Nuclear medicine business |
| Zdroj: | Calcified tissue international. 96(5) |
| ISSN: | 1432-0827 |
| Popis: | Purpose: This 11-year prospective longitudinal study examined how a pre-pubertal pediatric bone mass scan predicts peak bone mass. Methods: We measured bone mineral content (BMC; g), bone mineral density (BMD; g/cm2) and bone area (cm2) in femoral neck, total body and lumbar spine by dual energy X-ray absorptiometry (DXA) in a population based cohort including 65 boys and 56 girls. At baseline all participants were pre-pubertal with a mean age of 8 years (range 6-9), they were re-measured at a mean 11 years (range 10-12) later. The participants were then mean 19 years (range 18-19), an age range that corresponds to peak bone mass in femoral neck in our population. We calculated individual BMC, BMD and bone size Z-scores, using all participants at each measurement as reference and evaluated correlations between the two measurements. Individual Z-scores were also stratified in quartiles to register movements between quartiles from pre-pubertal age to peak bone mass. Results: The correlation coefficients (r) between pre-pubertal and young adulthood measurements for femoral neck BMC, BMD and bone area varied between 0.37-0.65. The reached BMC value at age 8 years explained 42% of the variance in the BMC peak value, the corresponding values for BMD was 31% and bone area 14%. Among the participants with femoral neck BMD in the lowest childhood quartile, 52% had left this quartile at peak bone mass. A pediatric bone scan with a femoral neck BMD value in the lowest quartile had a sensitivity of 47% (95% CI 28, 66) and a specificity of 82% (95% CI 72, 89) to identify individuals who would remain in the lowest quartile at peak bone mass. Conclusions: The pre-pubertal femoral neck BMD explained only 31% of the variance in femoral neck peak bone mass. A pre-pubertal BMD scan in a population based sample has poor ability to predict individuals who are at risk of low peak bone mass. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink