Studies on Trans-Resveratrol/Carboxymethylated (1,3/1,6)-β-d-Glucan Association for Aerosol Pharmaceutical Applications

Autor: Luciana Mosca, Paola Mastromarino, Antonio Francioso, Sergio Fanelli, Riccardo Cossi
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
beta-Glucans
Rhinovirus
aerosol
Resveratrol
Matrix (biology)
Pharmacology
resveratrol
lcsh:Chemistry
chemistry.chemical_compound
0302 clinical medicine
Stilbenes
carboxymethylated glucan
MMAD
lcsh:QH301-705.5
Spectroscopy
chemistry.chemical_classification
Chemistry
Anti-Inflammatory Agents
Non-Steroidal
General Medicine
Computer Science Applications
medicine.anatomical_structure
Cell Survival
Antiviral Agents
Catalysis
Article
Inorganic Chemistry
03 medical and health sciences
medicine
Humans
Physical and Theoretical Chemistry
Particle Size
Molecular Biology
Inhibitory effect
Glucan
Aerosols
Chromatography
Trans-resveratrol
Nebulizers and Vaporizers
Organic Chemistry
Aerosol
β d glucan
Nasal Mucosa
030104 developmental biology
030228 respiratory system
lcsh:Biology (General)
lcsh:QD1-999
Volatilization
Respiratory tract
HeLa Cells
Zdroj: International Journal of Molecular Sciences; Volume 18; Issue 5; Pages: 967
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 18, Iss 5, p 967 (2017)
ISSN: 1422-0067
DOI: 10.3390/ijms18050967
Popis: A resveratrol/carboxymethylated glucan (CM-glucan) combination is known to inhibit rhinovirus replication and expression of inflammatory mediators in nasal epithelia. The aim of this study was to develop an aerosol formulation containing an association of the two molecules which could reach the lower respiratory tract. Mass median aerodynamic diameter (MMAD) of a resveratrol/CM-glucan combination was lower than that shown by resveratrol or CM-glucan alone (2.83 versus 3.28 and 2.96 µm, respectively). The resveratrol/CM-glucan association results in the finest and most monodispersed particles in comparison to the two single components. The association also evidenced lower values for all particle size distribution parameters, suggesting that the pharmacological synergy observed in previous studies may be accompanied by a pharmaceutical one. Moreover, we showed that the CM-glucan matrix did not exert an inhibitory effect on resveratrol nebulization, demonstrating the good suitability of these two molecules in association for simultaneous aerosol volatilization.
Databáze: OpenAIRE
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