Improved dynamic response assessment for intra-articular injected iron oxide nanoparticles
| Autor: | Kerstin Grosdemange, J Salaklang, Anthony Redjem, Bénédicte M. A. Delattre, Frank Tobalem, Lindsey A. Crowe, Alke Petri-Fink, Jean-Paul Vallée, Heinrich Hofmann, Azza Gramoun |
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| Rok vydání: | 2012 |
| Předmět: |
Concentration Response
Chemistry Relaxation (NMR) Iron oxide Nanoparticle Imaging phantom 030218 nuclear medicine & medical imaging 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Intra articular Nuclear magnetic resonance In vivo Radiology Nuclear Medicine and imaging 030217 neurology & neurosurgery Iron oxide nanoparticles Biomedical engineering |
| Zdroj: | Magnetic Resonance in Medicine. 68:1544-1552 |
| ISSN: | 0740-3194 |
| DOI: | 10.1002/mrm.24166 |
| Popis: | The emerging importance of nanoparticle technology, including iron oxide nanoparticles for monitoring development, progression, and treatment of inflammatory diseases such as arthritis, drives development of imaging techniques. Studies require an imaging protocol that is sensitive and quantifiable for the detection of iron oxide over a wide range of concentrations. Conventional signal loss measurements of iron oxide nanoparticle containing tissues saturate at medium concentrations and show a nonlinear/nonproportional intensity to concentration profile due to the competing effects of T₁ and T₂ relaxation. A concentration calibration phantom and an in vivo study of intra-articular injection in a rat knee of known concentrations of iron oxide were assessed using the difference-ultrashort echo time sequence giving a positive, quantifiable, unambiguous iron signal and monotonic, increasing concentration response over a wide concentration range in the phantom with limited susceptibility artifacts and high contrast in vivo to all other tissues. This improved dynamic response to concentration opens possibilities for quantification due to its linear nature at physiologically relevant concentrations. |
| Databáze: | OpenAIRE |
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