Dopamine D3 (Auto)receptors Inhibit Dopamine Release in the Frontal Cortex of Freely Moving Rats In Vivo
| Autor: | Millan Mark, Alain P. Gobert, Laetitia Cistarelli, Françoise Lejeune, Jean-Michel Rivet |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Agonist medicine.medical_specialty Tegmentum Mesencephali medicine.drug_class Dopamine Microdialysis Biochemistry Cellular and Molecular Neuroscience chemistry.chemical_compound PD-128 907 Dopamine receptor D3 2-Naphthylamine Internal medicine Oxazines medicine Animals Benzopyrans Rats Wistar Furans Neurotransmitter Dose-Response Relationship Drug Receptors Dopamine D2 Receptors Dopamine D3 Receptor antagonist Frontal Lobe Rats Electrophysiology Ventral tegmental area medicine.anatomical_structure Endocrinology chemistry Dopamine Agonists Autoreceptor Dopamine Antagonists medicine.drug |
| Zdroj: | Journal of Neurochemistry. 66:2209-2212 |
| ISSN: | 1471-4159 0022-3042 |
| DOI: | 10.1046/j.1471-4159.1996.66052209.x |
| Popis: | In freely moving rats, the novel, selective dopamine (DA) D 3 receptor agonist PD 128,907 dose-dependently [effective dose (ED 25 ) = 0.07 mg/kg, s.c.] reduced dialysate levels of DA in the frontal cortex, a structure innervated by the ventral tegmental area (VTA). This action of PD 128,907 (0.16 mg/kg, s.c.) was abolished by a selective DA D 3 receptor antagonist S 14297 (1.25 mg/kg, s.c.), which alone did not modify levels of DA. In contrast to S 14297, its inactive distomer, S 17777, did not modify the actions of PD 128,907. In addition, PD 128,907 dose-dependently and potently inhibited the firing rate of VTA-localized neurons in anesthetized rats (ED 50 = 0.001 mg/kg, i.v.). S 14297, but not S 17777, completely reversed the actions of PD 128,907 (0.005 mg/kg, i.v.) with a 50% inhibitory dose of 0.03 mg/kg, i.v. and did not itself significantly modify the firing rate. In conclusion, these data provide the first direct evidence that DA D 3 (auto)receptors modulate (inhibit) the release of DA in the frontal cortex. |
| Databáze: | OpenAIRE |
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