The immature monkey as a model for studies of bronchopulmonary dysplasia
| Autor: | W. A. Hodson, William E. Truog, J. H. Murphy, Thomas A. Standaert, D. L. Kessler, D.L. Luchtel, S. Palmer |
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| Rok vydání: | 1979 |
| Předmět: |
Background information
Lung Diseases Pathology medicine.medical_specialty Hyaline Membrane Disease Bioinformatics Infant Newborn Diseases Pathogenesis Animal model Medicine Animals Humans Lung business.industry Infant Newborn Haplorhini medicine.disease Infant newborn Lung repair Disease Models Animal medicine.anatomical_structure Bronchopulmonary dysplasia Lung disease Pediatrics Perinatology and Child Health Macaca business |
| Zdroj: | The Journal of pediatrics. 95(5 Pt 2) |
| ISSN: | 0022-3476 |
| Popis: | Summary The monkey is a potential model for BPD since there is considerable background information on the normaldeveloping lung, the prematurely delivered infant is viable, HMD can be produced, the infant is large enough to permit physiologic measurements, and it should be possible to test the effects of positive pressure, oxygen, and pharmacologic agents. Clearly further information is needed on the cellular and subcellular changes occurring during the acute and recovery stages of HMD. The monkey has already proven to be of value in this inquiry. Studies on mechanisms of altered lung repair by various injurious agents are needed, and will require an animal model as well as in vitro systems. Basic understanding of the pathogenesis of bronchopulmonary dysplasia with establishment of the relative importance of the contributing factors should help in our efforts to prevent or minimize chronic lung disease in the newborn infant. |
| Databáze: | OpenAIRE |
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