Metabolism of (131-I)gamma globulins in patients with chronic liver disease
| Autor: | T. Fukuda, Takeji Toda, C. Hirayama |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Liver Cirrhosis
medicine.medical_specialty Cirrhosis Time Factors Clinical Biochemistry Normal values Chronic liver disease Biochemistry Gastroenterology Hepatitis Adrenal Cortex Hormones Internal medicine Iodine Isotopes Medicine Humans In patient Chronic Active business.industry Liver Diseases Biochemistry (medical) Gamma globulin General Medicine Metabolism medicine.disease Endocrinology gamma-Globulins business |
| Zdroj: | Clinica chimica acta; international journal of clinical chemistry. 27(3) |
| ISSN: | 0009-8981 |
| Popis: | The turnover of injected 131 I-labelled γ-globulins has been observed in control subjects and patients with non-alcoholic liver diseases. In control subjects, the half-life of γG was 14.1 days and the synthetic rate 52 mg/kg/day. In patients with chronic active hepatitis and liver cirrhosis, the half-life was reduced and the synthetic rate increased. Following treatment with corticosteroids, the synthetic rate was reduced in patients with liver cirrhosis. In γA studies, the normal values of the half-life and the synthetic rate were 6.2 days and 29 mg/kg/day, respectively. In cirrhosis patients the synthetic rate increased. In γM studies, the normal values of the half-life and the synthetic rate were 6.0 days and 6 mg/kg/day, respectively. In cirrhosis patients, the half-life was prolonged and the synthetic rate increased. |
| Databáze: | OpenAIRE |
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