Evaluation of the effects of atorvastatin on renal ischemia-reperfusion in diabetic rats
| Autor: | Saeed Purdian, Leila Pirmoradi, Foruzan Hosseini, Ramesh Rahagh |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
kidney
Medicine (General) medicine.medical_specialty Atorvastatin ischemia-reperfusion injury Ischemia Blood lipids Type 2 diabetes chemistry.chemical_compound R5-920 Blood serum Internal medicine medicine Creatinine Cholesterol business.industry atorvastatin General Medicine medicine.disease Endocrinology chemistry Low-density lipoprotein diabetes mellitus Medicine lipids (amino acids peptides and proteins) business medicine.drug |
| Zdroj: | مجله علمی دانشگاه علوم پزشکی کردستان, Vol 25, Iss 5, Pp 11-21 (2020) |
| ISSN: | 2345-4040 1560-652X |
| DOI: | 10.52547/sjku.25.5.11 |
| Popis: | Background and Aim: Statins are among extensively used medications in diabetic patients. This study was designed to assess the outcome of atorvastatin pretreatment in renal ischemia- reperfusion in diabetic rats. Material and Methods: Wistar male rats (180-230 gr) were divided into 5 groups: normal control (CN), atorvastatin control (5 mg/kg) (CA), diabetic control (CD), diabetic group receiving atorvastatin 0.5 mg/kg (DA/a), diabetic group receiving atorvastatin 5 mg/kg (DA/b). Affter induction of type II diabetes by injection of nicotinamide and streptozotocin, the rats received daily atorvastatin or normal saline gavage for 2 months. Then, under anesthesia ischemia was induced for 45 min followed by reperfusion for 24 h. Blood and urine samples were collected for the measurement of lipid profile and renal function indices. Statistical analysis was performed by one-way analysis of variance and Tukey post-hoc test. Results: Total cholesterol and LDL were reduced in the group receiving atorvastatin (5 mg/kg) (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|