Regulation of chemokine gene expression by contact hypersensitivity and by oral tolerance
| Autor: | Jack R. Battisto, Jennifer Major, Yunn-Shin Yuan |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
CCR1
CD4-Positive T-Lymphocytes Transcriptional Activation CCR2 Administration Topical T-Lymphocytes Administration Oral Picryl Chloride CD8-Positive T-Lymphocytes Dermatitis Contact CCL8 General Biochemistry Genetics and Molecular Biology Mice History and Philosophy of Science Immune Tolerance CXCL10 CCL17 Animals RNA Messenger CXCL13 CCL13 Skin Chemistry General Neuroscience Oxazolone Ear Molecular biology Gene Expression Regulation Chemokines Haptens Spleen CCL21 |
| Zdroj: | Annals of the New York Academy of Sciences. 778 |
| ISSN: | 0077-8923 |
| Popis: | In mice with hapten-induced CH, T cells of the CD4+ and CD8+ phenotypes activated the gene for JE, whereas CD8+ T cells alone caused activation of the gene for IP-10. In animals tolerized by feeding either TNCB or OX, hapten-induced expression of IP-10 but not JE mRNA was lost. The down-regulation of IP-10 gene activation was adoptively transferred from tolerized mice to naive mice by CD4+ splenic T cells. These findings reflect the differential roles of individual T-cell subsets in both enhancing and diminishing chemokine gene expression in contact hypersensitivity reactions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text