Preparation and mechanism of hydroxyapatite hollow microspheres with different surface charge by biomimetic method
| Autor: | Shangyou Xiao, Kebing Guo, Xiuying Yang, Zhenzhen Tian, Shilei Hao, Jingou Ji, Ting Lu |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
Surface Properties Scanning electron microscope 0206 medical engineering Biomedical Engineering Biophysics Nanoparticle Bioengineering 02 engineering and technology Polyethylene glycol Polyethylene Glycols Biomaterials chemistry.chemical_compound Drug Delivery Systems X-Ray Diffraction Biomimetics Specific surface area PEG ratio Surface charge High-resolution transmission electron microscopy technology industry and agriculture 021001 nanoscience & nanotechnology 020601 biomedical engineering Microspheres Durapatite chemistry Chemical engineering Microscopy Electron Scanning Nanoparticles 0210 nano-technology Powder diffraction |
| Zdroj: | Journal of Materials Science: Materials in Medicine. 31 |
| ISSN: | 1573-4838 0957-4530 |
| DOI: | 10.1007/s10856-020-06385-7 |
| Popis: | To meet the different application requirements in various fields, hydroxyapatite (HA) hollow microspheres with different surface charge were synthesized successfully by biomimetic method using Ca(NO3)2·4H2O and (NH4)2HPO4 in the presence of polyethylene glycol (PEG). Scanning electron microscopy (SEM), High-resolution TEM (HRTEM), X-ray powder diffraction (XRD), and Zeta PALS were used to characterize the obtained samples. The results indicated that the concentration of PEG and temperature significantly affect the morphology of the obtained samples. After incubation for 5 d, the HA hollow microspheres with positive surface charge, HA spherical nanoparticles with surface charge close to zero and calcium deficiency HA (d-HA) hollow microspheres with negative surface charge were obtained respectively in the presence of 5% PEG, 6% PEG and 7% PEG at 15 °C. Brunauer-Emmett-Teller (BET) revealed that the specific surface area of HA hollow microspheres reached 98.50 m2/g, while that of HA spherical nanoparticles were only 4.12 m2/g, hollow microspheres show a better application prospect. The possible formation mechanism was also discussed. |
| Databáze: | OpenAIRE |
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