The BBZDR/Wor Rat Model for Investigating the Complications of Type 2 Diabetes Mellitus
| Autor: | Tiangen Wu, Dennis L. Guberski, Edward H. Kislauskis, Rebecca S. Tirabassi, Joan F. Flanagan, Paul J Birckbichler |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Congenic Type 2 diabetes Disease medicine.disease_cause Rats Mutant Strains General Biochemistry Genetics and Molecular Biology Autoimmunity Diabetes Complications Inbred strain Internal medicine Diabetes mellitus medicine Animals Rats Inbred BB business.industry Strain (biology) Type 2 Diabetes Mellitus General Medicine medicine.disease Rats Rats Zucker Disease Models Animal Endocrinology Diabetes Mellitus Type 2 Animal Science and Zoology business |
| Zdroj: | ILAR Journal. 45:292-302 |
| ISSN: | 1084-2020 |
| DOI: | 10.1093/ilar.45.3.292 |
| Popis: | Congenic and inbred strains of rats offer researchers invaluable insight into the etiopathogenesis of diabetes and associated complications. The inbred Bio-Breeding Zucker diabetic rat (BBZDR)/Wor rat strain is a relatively new and emerging model of type 2 diabetes. This strain was created by classical breeding methods used to introgress the defective leptin receptor gene (Lepr(fa)) from insulin-resistant Zucker fatty rats into the inbred BBDR/Wor strain background. The diabetic male BBZDR/Wor rat is homozygous for the fatty mutation and shares the genetic background of the original BB strain. Although lean littermates are phenotypically normal, obese juvenile BBZDR/Wor rats are hyperlipidemic and hyperleptinemic, become insulin resistant, and ultimately develop hyperglycemia. Furthermore, the BBZDR/Wor rat is immune competent and does not develop autoimmunity. Similar to patients with clinical diabetes, the BBZDR/Wor rat develops complications associated with hyperglycemia. The BBZDR/Wor rat is a model system that fully encompasses the ability to study the complications that affect human type 2 diabetic patients. In this review, recent work that has evaluated type 2 diabetic complications in BBZDR/Wor rats is discussed, including the authors' preliminary unpublished studies on cardiovascular disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|