Gastric Adenocarcinoma of Fundic Gland Type with Aggressive Transformation and Lymph Node Metastasis: a Case Report
| Autor: | Koshi Kumagai, Yasuhiro Okumura, Hiroshi Kawachi, Naoki Hiki, Souya Nunobe, Manabu Ohashi, Takeshi Sano, Satoshi Ida, Manabu Takamatsu, Yorimasa Yamamoto, Noriko Yamamoto |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty medicine.medical_treatment Neoplasm metastasis Case Report Metastasis 03 medical and health sciences 0302 clinical medicine Submucosa Biopsy medicine Lymph node Lymph nodes medicine.diagnostic_test business.industry Gastric gland Gastroenterology Fundic Gland medicine.disease medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Tubular Adenocarcinoma 030211 gastroenterology & hepatology Gastrectomy Lymphadenectomy business |
| Zdroj: | Journal of Gastric Cancer |
| ISSN: | 2093-5641 2093-582X |
| Popis: | A 55-year-old man visited our hospital for a detailed examination of a gastric submucosal tumor that was first detected 10 years prior. The tumor continued to grow and had developed a depressed area in its center. A histopathological examination of biopsy specimens revealed gastric adenocarcinoma of the fundic gland type (GA-FG). It was diagnosed as T2 based on the invasion depth as determined by white-light endoscopy and endoscopic ultrasonography. A total gastrectomy with lymphadenectomy was performed and a GA-FG in the mucosa and submucosa was confirmed histopathologically. However, there was a gradual transition to an infiltrative tubular adenocarcinoma with poorly differentiated components in the muscular and subserosal layers. Metastasis was identified in a dissected lymph node (LN). This is the first report of a GA-FG progressing to an aggressive cancer with LN metastasis. These findings modify our understanding of the pathophysiology of GA-FG. |
| Databáze: | OpenAIRE |
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