Three new quassinoids isolated from the wood of Picrasma javanica and their anti-Vpr activities
| Autor: | Ahmad H El-Desoky, Chin Piow Wong, Maurice D. Awouafack, Hiroyuki Morita, Ikuro Abe, Alfarius Eko Nugroho, Hiroshi Morita, Hla Ngwe, Yi Yi Win, Prema, Takeshi Kodama |
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| Rok vydání: | 2020 |
| Předmět: |
food.ingredient
Traditional medicine Quassins 010405 organic chemistry Chemistry Anti-HIV Agents Plant Extracts Gene Products vpr Pharmacology toxicology Viral Protein R 01 natural sciences Wood 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound food Picrasma HIV-1 Molecular Medicine Methanol Picrasma javanica Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Journal of natural medicines. 74(3) |
| ISSN: | 1861-0293 |
| Popis: | Three new quassinoids, javanicinols A and B (1 and 2) and 4-keto-(16S)-methoxyjavanicin B (3), together with three known quassinoids (4-6) were isolated from the chloroform-soluble fraction of the methanol extract of the Picrasma javanica wood. The structures of 1-3 were determined by spectroscopic analyses, including 1D and 2D NMR, HRESIMS, and CD. The anti-HIV-1 viral protein R (Vpr) assay revealed that 1 and 2 exhibited potent anti-Vpr activities at 1.25 μM. Furthermore, the assay also revealed the potent anti-Vpr activities of (16R)-methoxyjavanicin B (7) and (16S)-methoxyjavanicin B (8), which were previously isolated from the Picrasma javanica wood. |
| Databáze: | OpenAIRE |
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