Glycemic Characteristics and Neonatal Outcomes of Women Treated for Mild Gestational Diabetes

Autor: Patrick M. Catalano, Susan M. Ramin, Anthony Sciscione, Garland D. Anderson, Lisa Mele, Jorge E. Tolosa, George R. Saade, Dwight J. Rouse, Brian M. Casey, Catherine Y. Spong, Michael W. Varner, Yoram Sorokin, Celeste Durnwald
Rok vydání: 2011
Předmět:
Zdroj: Obstetrics & Gynecology. 117:819-827
ISSN: 0029-7844
DOI: 10.1097/aog.0b013e31820fc6cf
Popis: To estimate the association between fasting and 2-hour postprandial blood glucose levels and neonatal outcomes in women treated for mild gestational diabetes. In this secondary analysis of a multicenter randomized treatment trial of mild gestational diabetes, the median fasting and 2-hour postprandial glucose levels were analyzed in 2-week intervals and change over time (slope) was calculated for women with gestational diabetes (abnormal oral glucose tolerance test) and a fasting glucose less than 95 mg/dL who received nutritional management with self blood glucose monitoring and insulin as needed. Regression analyses were performed to estimate the relationship between median fasting and postprandial glucose and neonatal fat mass, cord blood C-peptide, birth weight, large-for-gestational-age neonates, macrosomia (greater than 4,000 g), and neonatal hypoglycemia. Among 460 women with gestational diabetes, median fasting (P
Databáze: OpenAIRE