Positive Tuberculin Skin Test or Interferon-Gamma Release Assay in Patients with Radiographic Lesion Suggesting Old Healed Tuberculosis
| Autor: | Soon Ho Yoon, Seok-Chul Yang, S. K. Han, Sang Min Lee, Hyeon Kyoung Koo, Ji Sun Lee, Jae-Joon Yim, Hyo-Jeong Lim, Youngwhan Kim, Chul-Gyu Yoo, Yun-Jeong Jeong |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Tuberculosis Radiography Interferon gamma release assay Respiratory Diseases Tuberculin Lesion Risk Factors Internal medicine Medicine Humans Prospective Studies Risk factor Prospective cohort study Aged Aged 80 and over business.industry Tuberculin Test Age Factors General Medicine Skin test Pulmonary Middle Aged medicine.disease bacterial infections and mycoses Surgery Radiology and Other Imaging Original Article Female medicine.symptom business Interferon-gamma Release Tests |
| Zdroj: | Journal of Korean Medical Science |
| ISSN: | 1598-6357 1011-8934 |
| Popis: | Radiographic lesions suggesting old healed tuberculosis (TB) is considered a risk factor for the subsequent development of active TB. The aim of this study was to estimate the positive rates of tuberculin skin test (TST) and interferon-gamma release assay (IGRA) in persons with old healed TB. Participants with lesions suggesting old healed TB on chest images and controls without such lesions were prospectively enrolled between January 1, 2010, and January 31, 2011. TST and the QuantiFERON-TB Gold In-Tube test (QFT-GIT) were performed. In total, 193 participants with old healed TB and 126 controls were recruited. The rates of positive TST and QFT-GIT among patients with old healed TB were 54.6% and 77.7%, respectively. The rates of positive TST and QFT-GIT among patients without old healed TB were 38.9% and 61.9%. Sixteen percent of participants with old healed TB showed negative results by both TST and QFT-GIT. The positive rate of TST waned among participants with old healed TB who were older than 60 yr, whereas QFT-GIT positivity was unaffected by age. The positive rates of TST and IGRA among participants with radiographic lesions suggesting old healed TB was higher than without those lesions. In addition, IGRA may be more accurate than TST for the detection of latent TB infection, especially in populations of individuals older than 60 yr. |
| Databáze: | OpenAIRE |
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