The Story of RNA Folding, as Told in Epochs
| Autor: | Steve Bonilla, Daniel Herschlag, Namita Bisaria |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cognitive science RNA Folding Extramural Process (engineering) RNA Biology 010402 general chemistry 01 natural sciences General Biochemistry Genetics and Molecular Biology 0104 chemical sciences 03 medical and health sciences RNA world hypothesis 030104 developmental biology CONCEPT Models Chemical Animals Humans Thermodynamics Rna folding Nucleic acid structure Scientific disciplines Catalytic RNA |
| Zdroj: | Cold Spring Harb Perspect Biol |
| ISSN: | 1943-0264 |
| Popis: | The past decades have witnessed tremendous developments in our understanding of RNA biology. At the core of these advances have been studies aimed at discerning RNA structure and at understanding the forces that influence the RNA folding process. It is easy to take the present state of understanding for granted, but there is much to be learned by considering the path to our current understanding, which has been tortuous, with the birth and death of models, the adaptation of experimental tools originally developed for characterization of protein structure and catalysis, and the development of novel tools for probing RNA. In this review we tour the stages of RNA folding studies, considering them as "epochs" that can be generalized across scientific disciplines. These epochs span from the discovery of catalytic RNA, through biophysical insights into the putative primordial RNA World, to characterization of structured RNAs, the building and testing of models, and, finally, to the development of models with the potential to yield generalizable predictive and quantitative models for RNA conformational, thermodynamic, and kinetic behavior. We hope that this accounting will aid others as they navigate the many fascinating questions about RNA and its roles in biology, in the past, present, and future. |
| Databáze: | OpenAIRE |
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