3D Printed scaffolds with bactericidal activity aimed for bone tissue regeneration
| Autor: | Sónia P. Miguel, Ilídio J. Correia, António Mendonça, Tiago Ruivo Correia, Daniela Sofia Rodrigues Figueira, Kevin Domingos de Sá, R. Fradique |
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| Přispěvatelé: | uBibliorum |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Staphylococcus aureus
Bone Regeneration Silver Biocompatibility Cell Survival Surface Properties Population Metal Nanoparticles 02 engineering and technology Microbial Sensitivity Tests Bactericidal activity 010402 general chemistry Bone tissue 01 natural sciences Biochemistry Silver nanoparticle Tissue engineering Structural Biology medicine Humans education Bone regeneration Molecular Biology Cells Cultured education.field_of_study Tissue Scaffolds Chemistry Implant failure General Medicine 021001 nanoscience & nanotechnology Elasticity 0104 chemical sciences Anti-Bacterial Agents medicine.anatomical_structure Bone Substitutes Printing Three-Dimensional Rapid prototyping (RP) Implant Silver nanoparticles 0210 nano-technology Porosity Biomedical engineering |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação instacron:RCAAP |
| Popis: | Nowadays, the incidence of bone disorders has steeply ascended and it is expected to double in the next decade, especially due to the ageing of the worldwide population. Bone defects and fractures lead to reduced patient's quality of life. Autografts, allografts and xenografts have been used to overcome different types of bone injuries, although limited availability, immune rejection or implant failure demand the development of new bone replacements. Moreover, the bacterial colonization of bone substitutes is the main cause of implant rejection. To vanquish these drawbacks, researchers from tissue engineering area are currently using computer-aided design models or medical data to produce 3D scaffolds by Rapid Prototyping (RP). Herein, Tricalcium phosphate (TCP)/Sodium Alginate (SA) scaffolds were produced using RP and subsequently functionalized with silver nanoparticles (AgNPs) through two different incorporation methods. The obtained results revealed that the composite scaffolds produced by direct incorporation of AgNPs are the most suitable for being used in bone tissue regeneration since they present appropriate mechanical properties, biocompatibility and bactericidal activity. |
| Databáze: | OpenAIRE |
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