Novel Resveratrol-Based Aspirin Prodrugs: Synthesis, Metabolism, and Anticancer Activity
| Autor: | Junsheng Fu, Yuhuii Hu, Dominique N. Soroka, Yingdong Zhu, Xiaoxin Luke Chen, Shengmin Sang, Kelly Shurlknight |
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| Rok vydání: | 2015 |
| Předmět: |
Cell cycle checkpoint
Antineoplastic Agents Apoptosis Resveratrol Pharmacology Intestinal absorption Antioxidants chemistry.chemical_compound Mice Cell Line Tumor Cyclins Drug Discovery Stilbenes medicine Animals Humans Prodrugs Aspirin Caspase 3 Cell Cycle Prodrug Enzyme Activation Mice Inbred C57BL chemistry Intestinal Absorption Cancer cell Molecular Medicine Female Salicylic acid medicine.drug |
| Zdroj: | Journal of medicinal chemistry. 58(16) |
| ISSN: | 1520-4804 |
| Popis: | Regular aspirin use has been convincingly shown to reduce the risk of colorectal cancer. However, long-term use of aspirin leads to gastrotoxicity. Herein, we designed and synthesized a novel class of resveratrol-based aspirin prodrugs to simultaneously release aspirin and resveratrol to attenuate the side effects caused by aspirin. Prodrug RAH exerted enhanced anticancer activities which are better than a physical mixture of aspirin and resveratrol as well as each individually. Metabolism of RAH in mice showed that the majority of RAH is decomposed to release resveratrol and aspirin or salicylic acid either in the intestine or after absorption. Mechanistic studies demonstrate RAH inhibits cell cycle arrest through downregulation of cyclins and induces apoptosis by activation of caspase-3 in cancer cells. These findings highlighted the improved anticancer properties of resveratrol-based aspirin prodrugs. RAH may represent novel and safe alternatives of aspirin for the purpose of daily use in the future. |
| Databáze: | OpenAIRE |
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