Seropositivity of COVID-19 among asymptomatic healthcare workers: A multi-site prospective cohort study from Northern Virginia, United States
| Autor: | Emanuel F. Petricoin, Lance A. Liotta, Stephanie Garofalo, Brian C Moore, Rachel Bell, Scott A. Bruce, Eric R. Houpt, Christopher DeFilippi, Siqi Wei, G. Larry Maxwell, Amanda Haymond, David Trump, Abdulla A. Damluji |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
COVID-19
Coronavirus disease 2019 business.industry HCW Healthcare worker Incidence (epidemiology) Serologic test Ethnic group Immunity COVID-19 CIA Chemiluminescent immunoassay Logistic regression SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 Asymptomatic Public health surveillance ZIP Zone Improvement Plan Health care medicine PPE Personal protective equipment Seroconversion medicine.symptom Public aspects of medicine RA1-1270 Prospective cohort study business Research Paper Demography |
| Zdroj: | The Lancet Regional Health. Americas, Vol 2, Iss, Pp 100030-(2021) The Lancet Regional Health-Americas |
| Popis: | Background Because of their direct patient contact, healthcare workers (HCW) face an unprecedented risk of exposure to COVID-19. The aim of this study was to examine incidence of COVID-19 disease among asymptomatic HCW and community participants in Northern Virginia during 6 months of follow-up. Methods This is a prospective cohort study that enrolled healthy HCW and residents who never had a symptomatic COVID-19 infection prior to enrolment from the community in Northern Virginia from April to November 2020. All participants were invited to enrol in study, and they were followed at 2-, and 6-months intervals. Participants were evaluated by commercial chemiluminescence SARS-CoV-2 serology assays as part of regional health system and public health surveillance program to monitor the spread of COVID-19 disease. Findings Of a total of 1,819 asymptomatic HCW enrolled, 1,473 (96%) had data at two-months interval, and 1,323 (73%) participants had data at 6-months interval. At baseline, 21 (1.15%) were found to have prior COVID-19 exposure. At two-months interval, COVID-19 rate was 2.8% and at six months follow-up, the overall incidence rate increased to 4.8%, but was as high as 7.9% among those who belong to the youngest age group (20–29 years). Seroconversion rates in HCW were comparable to the seropositive rates in the Northern Virginia community. The overall incidence of COVID-19 in the community was 4.5%, but the estimate was higher among Hispanic ethnicity (incidence rate = 15.3%) potentially reflecting different socio-economic factors among the community participants and the HCW group. Using cross-sectional logistic regression and spatio-temporal mixed effects models, significant factors that influence the transmission rate among HCW include age, race/ethnicity, resident ZIP-code, and household exposure, but not direct patient contact. Interpretation In Northern Virginia, the seropositive rate of COVID-19 disease among HCW was comparable to that in the community. |
| Databáze: | OpenAIRE |
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